PMID: 1194665Oct 1, 1975Paper

N-acetyl-beta-glucosaminidase activity in normal and malignant leukocytes

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
C E Reed, J M Bennett

Abstract

An improved cytochemical method demonstrating N-acetyl-beta-glucosaminidase in peripheral blood and bone marrow leukocytes is described. A significant elevation in enzyme activity in circulating monocytes from patients with solid tumor malignancies was observed. In a large series of cases of acute nonlymphocytic leukemia, elevated levels were found in the vast majority of those leukemias that had a predominant monocytic component identified either morphologically or by standard cytochemical methods. This reaction would appear to be useful as a monocyte marker.

Citations

Apr 2, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·A D CrockardJ M Bridges
Jan 1, 1987·Cancer Investigation·A OrlacchioS Davis
Jan 1, 1984·The Anatomical Record·S P SorokinM M Grant
Sep 1, 1980·Scandinavian Journal of Haematology·A D Crockard, T C Morris
Apr 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M E ElsafiU Stenram
Jan 3, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·K C LeungC Y Lee
Dec 1, 1986·Biochemical Medicine and Metabolic Biology·A OrlacchioS Davis

❮ Previous
Next ❯

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.