N-Acetyl-Seryl-Aspartyl-Lysyl-Proline: mechanisms of renal protection in mouse model of systemic lupus erythematosus

American Journal of Physiology. Renal Physiology
Tang-Dong LiaoOscar A Carretero

Abstract

Systemic lupus erythematosus is an autoimmune disease characterized by the development of auto antibodies against a variety of self-antigens and deposition of immune complexes that lead to inflammation, fibrosis, and end-organ damage. Up to 60% of lupus patients develop nephritis and renal dysfunction leading to kidney failure. N-acetyl-seryl-aspartyl-lysyl-proline, i.e., Ac-SDKP, is a natural tetrapeptide that in hypertension prevents inflammation and fibrosis in heart, kidney, and vasculature. In experimental autoimmune myocarditis, Ac-SDKP prevents cardiac dysfunction by decreasing innate and adaptive immunity. It has also been reported that Ac-SDKP ameliorates lupus nephritis in mice. We hypothesize that Ac-SDKP prevents lupus nephritis in mice by decreasing complement C5-9, proinflammatory cytokines, and immune cell infiltration. Lupus mice treated with Ac-SDKP for 20 wk had significantly lower renal levels of macrophage and T cell infiltration and proinflammatory chemokine/cytokines. In addition, our data demonstrate for the first time that in lupus mouse Ac-SDKP prevented the increase in complement C5-9, RANTES, MCP-5, and ICAM-1 kidney expression and it prevented the decline of glomerular filtration rate. Ac-SDKP-treate...Continue Reading

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Citations

May 5, 2018·Expert Opinion on Biological Therapy·Elisavet VasilopoulouDavid A Long
Nov 8, 2018·American Journal of Physiology. Renal Physiology·Cesar A RomeroOscar A Carretero
Mar 12, 2019·Canadian Journal of Physiology and Pharmacology·Kamal M KassemNour-Eddine Rhaleb
Jan 25, 2018·PloS One·Pablo NakagawaOscar A Carretero
Apr 3, 2021·Molecular and Cellular Endocrinology·Elena Cantero-NavarroAlberto Ortiz

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