N-acetylcysteine and/or ascorbic acid versus placebo to prevent contrast-induced nephropathy in patients undergoing elective cardiac catheterization: The NAPCIN trial; A single-center, prospective, randomized trial

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Mohammed HabibAmen Hammad

Abstract

Several protective measures have been described to prevent contrast-induced nephropathy (CIN). This study is aimed to evaluate the effect of a high dose of N-acetylcysteine (NAC) plus hydration, a low dose of NAC plus ascorbic acid and hydration or hydration alone on the prevention of CIN in high-risk patients undergoing elective coronary artery intervention. We conducted a randomized, prospective, placebo-controlled trial of 105 high-risk patients undergoing elective cardiac catheterization. The patients were divided into three different groups: Group A (n=30), NAC 1200 mg orally before angiography and 1200 mg orally twice daily for three doses along with good hydration; Group B (n=30), NAC 600 mg before angiography and 600 mg orally twice daily for three doses plus ascorbic acid (3000 mg one dose) before angiography and 2000 mg two doses after angiography and good hydration; and Group C (n=45), hydration with 0.9% saline started just before contrast media injection and continued for 12 h at a rate 1.0 mL/kg//min after angiography or 0.5 mL/kg/h in cases with overt heart failure for 12 h. CIN was defined as an increase in serum creatinine of >25% of baseline or an absolute increase of 0.5 mg/dL above baseline after 48 h. The i...Continue Reading

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Citations

Apr 11, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Yongxing XuZhaoyan Gu
Nov 12, 2019·Clinical and Experimental Nephrology·Yoshitaka IsakaUNKNOWN Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Joint Working Group
Nov 12, 2019·Japanese Journal of Radiology·Yoshitaka IsakaUNKNOWN Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Joint Working Group
Dec 17, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Peter CalverleyAlberto Papi
Apr 13, 2021·Indian Journal of Nephrology·Mohammad Reza KhatamiHassan Aghajani
Nov 12, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka IsakaUNKNOWN Japanese Circulation Society Joint Working Group

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