PMID: 7546156Jan 1, 1995Paper

N-acetylcysteine failed to improve early microcirculatory alterations of the rat liver after transplantation

Transplant International : Official Journal of the European Society for Organ Transplantation
F WalcherR Larsen

Abstract

The application of radical scavengers reduces reperfusion injury of liver grafts despite the natural occurrence of cellular defense mechanisms enabling the cell to tolerate moderate oxidant stress without further cell damage. The glutathione peroxidase mechanism of the liver serves to reduce hydroxyl radical-induced lipid peroxidation by releasing reduced glutathione from intracellular stores. There is evidence that the application of cysteine-providing amino acids for glutathione synthesis could maintain or even increase liver glutathione. Therefore, the purpose of this study was to evaluate the effect of N-acetylcysteine (NAC) on oxidative stress-induced reperfusion injury after liver transplantation. This was done by applying intravital microscopy. Livers from female Sprague-Dawley rats weighing 220-260 g were stored for 20 h in University of Wisconsin (UW) solution and transplanted orthotopically using the cuff technique. Donors were given 150 mg/kg body weight NAC i.v. or placebo in a blind, random fashion 6 h prior to harvesting, followed by two injections of 50 mg/kg body weight, 4 and 2 h before explantation. In additional experimental groups, recipients were given a bolus of 83 mg/kg body weight NAC or placebo at the b...Continue Reading

References

May 1, 1992·Transplant International : Official Journal of the European Society for Organ Transplantation·J C García-ValdecasasJ Visa
Feb 1, 1991·The Journal of Cell Biology·K D PatelT M McIntyre
Nov 15, 1991·Klinische Wochenschrift·R Ruffmann, A Wendel
Apr 1, 1991·Transplant International : Official Journal of the European Society for Organ Transplantation·I MarziO Trentz
Jan 1, 1991·Free Radical Research Communications·H Jaeschke
Apr 1, 1991·Cryobiology·P K VreugdenhilJ H Southard
Sep 1, 1990·Transplantation·J D LangstonD R Luke
Aug 1, 1987·Journal of Clinical Pathology·S A JahanmehrJ E Maciver
Jan 1, 1989·Free Radical Biology & Medicine·H de Groot, A Littauer
Apr 1, 1988·Transplantation·F O Belzer, J H Southard
Apr 1, 1988·The Journal of Clinical Investigation·H JaeschkeJ R Mitchell
Mar 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D L TribbleD P Jones
Apr 1, 1985·Biochemical Pharmacology·H Jaeschke, A Wendel
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M WilliamsonA Meister

❮ Previous
Next ❯

Citations

Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Farin AmersiMarcus A Horwitz
Mar 28, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A SteibK Boudjema
Sep 24, 2008·Clinical and Experimental Medicine·Mevlut Sait KelesKonca Altinkaynak
Jan 19, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Santhalingam Jegatheeswaran, Ajith K Siriwardena

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
T A KoeppelS Post
Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Michael KretzschmarWulf Schirrmeister
European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
J BaumannL Bogar
© 2021 Meta ULC. All rights reserved