N-acetylcysteine improves hemodynamics and reduces oxidative stress in the brains of newborn piglets with hypoxia-reoxygenation injury

Journal of Neurotrauma
Jiang-Qin LiuPo-Yin Cheung

Abstract

Reactive oxygen species have been implicated in the pathogenesis of hypoxic-ischemic injury. It has been shown previously that treating an animal with N-acetyl-L-cysteine (NAC), a scavenger of free radicals, significantly minimizes hypoxic-ischemic-induced brain injury in various acute models. Using a subacute swine model of neonatal hypoxia-reoxygenation (H-R), we evaluated the long-term beneficial effect of NAC against oxidative stress-induced brain injury. Newborn piglets were randomly assigned to a sham-operated group (without H-R, n = 6), and two H-R experimental groups (n = 8 each), with 2 h normocapnic alveolar hypoxia and 1 h of 100% oxygen reoxygenation followed by 21% oxygen for 47 h. Five minutes after reoxygenation, the H-R piglets received either normal saline (H-R controls) or NAC (150 mg/kg bolus and 20 mg/kg/h IV for 24 h) in a blinded randomized fashion. Treating the piglets with NAC significantly increased both common carotid arterial flow (CCAF) and oxygen delivery during the early phase of rexoygenation, while both CCAF and carotid oxygen delivery of the H-R group remained lower than the sham-operated groups throughout the experimental period. Compared with H-R controls, significantly higher amounts of anest...Continue Reading

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Citations

Jan 5, 2011·Journal of Biomedicine & Biotechnology·Ming-Chi Lai, San-Nan Yang
Nov 14, 2013·PloS One·Xiaoping DuRichard D Kopke
Sep 10, 2013·Journal of Veterinary Internal Medicine·N D JefferyV M Stein
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Jan 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rukhmani NarayanamurthyLarry D Unsworth

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