PMID: 16517958Mar 7, 2006Paper

N-acetylcysteine is a highly available precursor for cysteine in the neonatal piglet receiving parenteral nutrition

JPEN. Journal of Parenteral and Enteral Nutrition
Anna K ShovellerRonald O Ball

Abstract

Cysteine (CYS) is accepted as an indispensable amino acid for infants receiving parenteral nutrition (PN), and CYS is unstable in solution. Thus, developing a method to supply CYS in PN for neonates is needed. N-acetyl-L-cysteine (NAC) is stable in solution and safe for use in humans; therefore, NAC may be a means of supplying parenteral CYS. We determined the bioavailability of NAC in intravenously (IV)-fed piglets randomized to 1 of 4 diet treatments, each supplying 0.3 g/kg/d methionine and either 0.2 g/kg/d CYS (CON), 0 NAC (zeroNAC), 0.13 NAC (lowNAC), or 0.27 g/kg/d NAC (highNAC). Piglets (2 days old; 1.8 kg, n = 20) were surgically implanted with femoral and jugular catheters. On day 3 postsurgery, test diets were initiated and continued until day 8. Piglets were weighed daily. Blood was sampled 6 hours before test diet initiation and at 0, 6, 12, 18, 24, 36, 48, 60, 72, 84, 96, 108, and 120 hours. Urine was collected on ice in 24-hour sample periods. Total mean weight gain was not different between groups; however, average daily gain in the zeroNAC and lowNAC groups declined significantly (p < .05) over the 5-day treatment period. Nitrogen retention was similar between the CON and highNAC groups, both were higher than t...Continue Reading

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Citations

Sep 18, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Hua-Yu LianJing-He Tan
Jan 25, 2018·Annals of the New York Academy of Sciences·Anna K ShovellerJohn P Cant
Mar 21, 2007·Journal of Animal Science·R N Dilger, D H Baker
Jan 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Diana R MagerPaul B Pencharz
Oct 1, 2019·Journal of Pediatric Gastroenterology and Nutrition·Lee-Anne HuberRobert F Bertolo

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