N-Acetylcysteine Restores Sevoflurane Postconditioning Cardioprotection against Myocardial Ischemia-Reperfusion Injury in Diabetic Rats

Journal of Diabetes Research
Jiefu LinZhengyuan Xia

Abstract

The effect of sevoflurane postconditioning (sevo-postC) cardioprotection is compromised in diabetes which is associated with increased oxidative stress. We hypothesized that antioxidant N-Acetylcysteine may enhance or restore sevo-postC cardioprotection in diabetes. Control or streptozotocin-induced Type 1 diabetic rats were either untreated or treated with N-Acetylcysteine for four weeks starting at five weeks after streptozotocin injection and were subjected to myocardial ischemia-reperfusion injury (IRI), in the absence or presence of sevo-postC. Diabetes showed reduction of cardiac STAT3 activation (p-STAT3) and adiponectin with concomitantly increase of FoxO1 and CD36, which associated with reduced sevo-postC cardioprotection. N-Acetylcysteine and sevo-postC synergistically reduced the infarct size in diabetic groups. N-Acetylcysteine remarkably increased cardiac p-STAT3 which was further enhanced by sevo-postC. N-Acetylcysteine but not sevo-postC decreased myocardial FoxO1 while sevo-postC but not N-Acetylcysteine significantly increased myocardiac adiponectin in diabetic rats. It is concluded that late stage diabetic rats displayed reduction of cardiac p-STAT3, adiponectin deficiency, and increase of FoxO1 and CD36 expre...Continue Reading

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Citations

Apr 7, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Phiwayinkosi V DludlaBongani B Nkambule
Nov 12, 2019·Frontiers in Cardiovascular Medicine·Zeina HarhousMazen Kurdi
Sep 3, 2020·Einstein·Mariela Carolina Santos CarballoMarcus Vinicius Henriques Brito
Nov 20, 2020·Cardiovascular Research·Hongyang ShuDao Wen Wang
Aug 21, 2021·International Journal of General Medicine·Chan Li, Zhaoya Liu

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SPSS
Image J

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