N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington's disease

Neuro-degenerative Diseases
Rajat SandhirSukhdev S Kamboj

Abstract

Mitochondrial dysfunction is a major event involved in the pathogenesis of Huntington's disease (HD). The present study evaluates the role of N-acetyl-L-cysteine (NAC) in preventing mitochondrial dysfunctions in a 3-nitropropionic acid (3-NP)-induced model of HD. Administration of 3-NP to rats (Wistar strain) resulted in significant inhibition of mitochondrial complexes II, IV and V in the striatum. However, no significant effect on complex I was observed. Increased generation of reactive oxygen species and lipid peroxidation was observed in mitochondria of 3-NP-treated animals. Endogenous antioxidants (thiols and manganese-superoxide dismutase) were lowered in mitochondria of 3-NP-treated animals. 3-NP-treated animals showed increased cytosolic cytochrome c levels and mitochondrial swelling. Increased expressions of caspase-3 and p53 were also observed in 3-NP-treated animals. Histopathological examination of the striata of 3-NP-treated animals revealed increased neural space, neurodegeneration and gliosis. This was accompanied by cognitive and motor deficits. NAC treatment, on the other hand, was found to be effective in reversing 3-NP-induced mitochondrial dysfunctions and neurobehavioral deficits. Our findings suggest a ben...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1976·Advances in Experimental Medicine and Biology·T E KingJ T Wu
Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Apr 1, 1974·Journal of Neuropathology and Experimental Neurology·I Tellez-NagelR D Terry
Jun 1, 1993·Analytical Biochemistry·J C Roberts, D J Francetic
Mar 1, 1996·Annals of Neurology·M GuA H Schapira
Aug 1, 1996·Neurochemistry International·J B SchulzM F Beal
Jan 14, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M A Pérez-PinzónT J Sick
Jun 4, 1999·Trends in Neurosciences·P H ReddyD A Tagle
Sep 18, 1999·Free Radical Biology & Medicine·H Wang, J A Joseph
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G W KimP H Chan
Feb 17, 2000·Neurochemistry International·C B PocernichD A Butterfield
Mar 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·T WeiW Xin
May 10, 2000·Nature Medicine·G Kroemer, J C Reed
Jun 17, 2000·Trends in Neurosciences·M F Beal
Sep 7, 2000·The Journal of Comparative Neurology·L LeventhalS Palfi
Oct 26, 2000·Trends in Biochemical Sciences·S Raha, B H Robinson
May 1, 2001·Free Radical Research·L A Macmillan-Crow, D L Cruthirds
Jul 21, 2001·Annals of the New York Academy of Sciences·A C ScalletZ K Binienda
Aug 8, 2001·Brain Research Bulletin·R Cruz-AguadoJ Bergado
Feb 28, 2002·The Journal of Biological Chemistry·Tsu-Kung LinMichael P Murphy
Jul 27, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gyung W Kim, Pak H Chan
Jul 9, 2003·Annals of the New York Academy of Sciences·Gary FiskumChristos Chinopoulos
May 1, 1958·Biochimica Et Biophysica Acta·H TEDESCHI, D L HARRIS

❮ Previous
Next ❯

Citations

Dec 4, 2012·Nutrients·William M JohnsonJohn J Mieyal
Apr 8, 2014·Pharmacology, Biochemistry, and Behavior·Surbhi Gupta, Bhupesh Sharma
Jul 17, 2014·Oxidative Medicine and Cellular Longevity·Zhengtang QiShuzhe Ding
May 6, 2015·Der Nervenarzt·J D Rollnik
May 11, 2015·Neuroscience and Biobehavioral Reviews·DeepmalaRichard Frye
May 5, 2016·Mechanisms of Ageing and Development·G K ShinomolM M Srinivas Bharath
Sep 18, 2015·The Australian and New Zealand Journal of Psychiatry·Michael Berk
May 8, 2014·The Australian and New Zealand Journal of Psychiatry·Justin DavisMichael Berk
Dec 3, 2016·Free Radical Biology & Medicine·Naomi LomeliDaniela A Bota
Apr 20, 2018·Expert Opinion on Therapeutic Targets·Ana SaavedraJordi Alberch
Apr 1, 2014·Brain and Behavior·Reza Bavarsad ShahripourAndrei V Alexandrov
Mar 5, 2020·Biochemical Society Transactions·Srinivasa Subramaniam
Jan 12, 2019·Neurotoxicity Research·Musthafa Mohamed EssaMohammed Akbar
Jan 1, 2014·Molecular and Cellular Biochemistry·J ChakrabortyK P Mohanakumar
Mar 30, 2018·The International Journal of Neuropsychopharmacology·Círia PereiraOlivia May Dean
Jan 3, 2019·Neuromolecular Medicine·Yajing MiXingchun Gou
May 7, 2020·Biomolecules·Piergiorgio La RosaFiorella Piemonte
Nov 16, 2017·Metabolic Brain Disease·Saurabh DhandaRajat Sandhir
Jul 8, 2020·Antioxidants·José Bono-YagüeRafael Pascual Vázquez-Manrique
Oct 25, 2017·Indian Journal of Clinical Biochemistry : IJCB·Rajat SandhirSaurabh Dhanda
Jun 6, 2020·Antioxidants & Redox Signaling·Lígia Fão, Ana Cristina Rego
Apr 4, 2019·Frontiers in Molecular Neuroscience·Bindu D Paul, Solomon H Snyder
Aug 16, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edward J CalabreseRehana K Leak
Nov 13, 2012·Experimental Cell Research·Samanta Oliveira LoureiroAngela T S Wyse
Sep 4, 2021·Neurotoxicology·Flavia Tasmin Techera AntunesEliane Dallegrave

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