PMID: 9447249Feb 3, 1998Paper

N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster

Cellular and Molecular Life Sciences : CMLS
C BrackM Labuhn

Abstract

Ageing can be defined as the time-dependent decline of physiological functions of an organism. The molecular causes for the ageing process are multiple, involving both genetic and environmental factors. It has been proposed that antioxidants may positively influence the ageing process, protecting the organism against free radical-induced damage. Here we show that the antioxidant N-acetylcysteine (NAC) has a life-extending effect on Drosophila melanogaster. Dietary uptake of NAC results in a dose-dependent increase in median and maximum life span. Flies fed on 1 mg/ml NAC food live 16.6% longer; at 10 mg/ml, life span increases by 26.6%. We have examined the effect of NAC treatment on protein and RNA levels: we observe an NAC-dependent increase in absolute amounts of total RNA and ribosomal RNA, but no differences in protein levels. The NAC effect on longevity may involve differential expression of specific mRNA genes, as suggested by RNA finger-printing experiments.

Citations

Sep 1, 2005·Age·Ronny HaenoldToshinori Hoshi
Sep 1, 2005·Age·Gordon J LithgowJames N Sampayo
Oct 17, 2001·Experimental Gerontology·I Irminger-Finger, C Sieber
Feb 13, 2014·Ageing and Society·Elisabeth Schröder-Butterfill, Tengku Syawila Fithry
Jul 29, 2003·Aging Cell·Tamara R GoldenSimon Melov
Sep 4, 2010·Antioxidants & Redox Signaling·Subramaniam Ponnappan, Usha Ponnappan
Oct 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nuzha M A TahoeJames W Curtsinger
Jan 29, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tingting ZhaoZhien Li
Jan 18, 2013·BioFactors·Li-Rong ShenChao-Qiang Lai
Dec 4, 2013·Free Radical Biology & Medicine·Ziyan ZhangHonglian Shi
Jul 10, 2012·Ageing Research Reviews·Mark LucanicSilvestre Alavez
Mar 12, 2010·Dose-response : a Publication of International Hormesis Society·Alexander M Vaiserman
May 28, 2011·Free Radical Biology & Medicine·Priti AzadGabriel G Haddad
Apr 16, 2016·F1000Research·Surinder Kumar, David B Lombard
Jan 17, 2019·Medicinal Research Reviews·Jan MartelJohn D Young
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Geneviève MorrowRobert M Tanguay
Oct 3, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R J MockettW C Orr
May 1, 2019·Antioxidants·Špela ŠalamonIrina Milisav
Dec 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aliabbas ZiaSaeed Samarghandian
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Hazel J ShieldsJeremy M Van Raamsdonk
Oct 5, 2021·Frontiers in Genetics·Enrique RodríguezNick Lane

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