PMID: 18708687Aug 19, 2008Paper

N-acetylcysteine supplementation and oxidative damage and inflammatory response after eccentric exercise

International Journal of Sport Nutrition and Exercise Metabolism
Luciano A SilvaRicardo A Pinho

Abstract

The objective of the study was to verify the effect of N-acetylcysteine (NAC) supplementation on parameters of oxidative damage and inflammatory response after high-intensity eccentric exercise (EE). 29 participants with a mean age of 21.3+/-4 yr, weight of 74.5+/-7.7 kg, and height of 177.2+/-6.9 cm were selected and divided randomly into 3 groups: placebo (21 days; n=8), NAC (21 days; n=9), and NAC plus placebo (14 days; n=8). Four participants withdrew from the study for personal reasons. 14 days after starting supplementation, the participants performed EE: 3 sets until exhaustion (elbow flexion and extension on the Scott bench, 80% 1RM). Blood samples were collected before and on the 2nd, 4th, and 7th day after EE. Muscle soreness (MS), lipoperoxidation, protein carbonylation, tumor-necrosis factor- (TNF-), and interleukin 10 (IL-10) were determined. Results showed a significant increase in MS in all the groups on the 2nd day after EE and a decrease in the following days. A significant increase was observed in malondialdehyde and carbonyl levels on the 4th and 7th days after EE in all groups. TNF- increased significantly on the 2nd day after eccentric exercise and decreased in the following days irrespective of NAC supplem...Continue Reading

Citations

Oct 28, 2009·The Journal of Physiological Sciences : JPS·Luciano A SilvaRicardo A Pinho
Dec 8, 2009·Amino Acids·Chad M KerksickDarryn S Willoughby
Nov 28, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Débora L SchefferRicardo A Pinho
Nov 18, 2018·Journal of Exercise Rehabilitation·Alan de Jesus Pires de MoraesMagnus Benetti
Dec 5, 2018·Free Radical Research·Giulia GoriniFrancesca Magherini
Apr 7, 2010·European Journal of Applied Physiology·Chris M DepnerMary P Miles
Jan 26, 2011·Cell Biochemistry and Function·Luciano A SilvaRicardo A Pinho
Jan 15, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L A SilvaR A Pinho
Jan 5, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Luciano A da SilvaRicardo Aurino Pinho
Dec 17, 2009·Medicine and Science in Sports and Exercise·Maria KalafatiDimitris Kouretas
May 17, 2011·European Journal of Applied Physiology·Ricardo A PinhoClaudio T Souza
Aug 19, 2009·Antioxidants & Redox Signaling·Esther Barreiro, Sabah N A Hussain
Nov 21, 2015·The Journal of Physiology·Michael B Reid
Dec 15, 2017·The Cochrane Database of Systematic Reviews·Mayur K RanchordasJoseph T Costello
Jun 30, 2018·Journal of Dietary Supplements·Kate M RhodesAndrea J Braakhuis
Aug 21, 2014·Journal of the American College of Nutrition·William J KraemerCarl M Maresh
Jul 29, 2018·British Journal of Sports Medicine·Mayur K RanchordasJoseph T Costello
Oct 17, 2020·Journal of Dietary Supplements·Fernando Naclerio PhDEneko Larumbe-Zabala PhD

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