N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin

Chemico-biological Interactions
Michael da CostaMaria E Pereira

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder pathologically characterized by severe neuronal and glial structural changes and progressive cognitive decline. N-acetylcysteine (NAC) is a well-known pharmacological agent with pro-neurogenic properties and neuroprotective effects. In this study, we evaluated NAC protective effects on cognitive impairment and associated pathological markers in a streptozotocin (STZ)-induced sporadic dementia of AD type mice model. Animals were divided into six groups: I) Sham, II) NAC, III) physostigmine (PHY), IV) STZ, V) NAC + STZ and VI) PHY + NAC. NAC (5 mg/kg) and PHY (0.25 mg/kg) were administrated orally for 30 consecutive days and STZ (2.5 mg/kg) intracerebroventricularly at the first and third days. Novel object recognition (NOR, days 26-27) and Morris water maze (MWM, days 26-30) tasks were assessed to evaluate learning and memory. On the thirty-first day animals were euthanized and brains collected for biochemical analysis. Interestingly, our results showed that STZ treatment induced cognitive impairment in mice in the NOR and MWM tasks. Both NAC and PHY treatments prevented from this impairment. The increase in AChE activity and decrease in pTrkB and MnSOD levels caused by ST...Continue Reading

References

Dec 1, 1986·Journal of Pharmacological Methods·S E Laursen, J K Belknap
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Aug 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K Plaschke, S Hoyer
Feb 1, 1996·Pharmacology, Biochemistry, and Behavior·L BartoliniG Pepeu
Dec 1, 1996·Journal of Neurocytology·M E CalhounP R Mouton
Aug 1, 1997·Journal of Neuropathology and Experimental Neurology·C I SzeL J Martin
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·P T FrancisG K Wilcock
Jul 19, 2001·The Surgical Clinics of North America·R Brentjens, L Saltz
Aug 23, 2001·Brain Research. Brain Research Reviews·R D'Hooge, P P De Deyn
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Oct 9, 2001·Mechanisms of Ageing and Development·V N Talesa
Apr 30, 2003·Journal of Pharmacological Sciences·Kiyofumi Yamada, Toshitaka Nabeshima
Mar 1, 1957·British Journal of Pharmacology and Chemotherapy·T J HALEY, W G MCCORMICK
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Jun 11, 2004·Clinical Neuropharmacology·Roger M LaneNigel H Greig
Oct 21, 2004·The Journal of Pathology·Milos Pekny, Marcela Pekna
Dec 8, 2004·Pharmacology, Biochemistry, and Behavior·Mojmir MachJames B Lucot
Apr 22, 2006·Journal of Alzheimer's Disease : JAD·Nataniel Lester-CollSuzanne M de la Monte
Oct 19, 2007·Neurobiology of Learning and Memory·Yuan LuBai Lu
Feb 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pedro BekinschteinJorge H Medina
Nov 4, 2009·Journal of Diabetes Science and Technology·Suzanne M de la Monte, Jack R Wands
Dec 17, 2009·Acta Neuropathologica·Michael V Sofroniew, Harry V Vinters
Dec 23, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rahul AgrawalRakesh Shukla
Sep 14, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M FigueiróE Elisabetsky
Oct 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davide TampelliniGunnar K Gouras
Nov 27, 2010·Behavioural Brain Research·Inge KlinkenbergArjan Blokland
Sep 11, 2012·The Journal of Nutritional Biochemistry·Simone PintonCristina Wayne Nogueira
Oct 11, 2012·Neurochemistry International·Gabriela K FerreiraEmilio L Streck
Jul 16, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mark W AlbersLi I Zhang
Oct 1, 2015·Antioxidants & Redox Signaling·Anja KonzackThomas Kietzmann
Jan 23, 2016·Progress in Neurobiology·Lana M OsbornElly M Hol
Apr 19, 2016·Chemico-biological Interactions·Michael CostaMaria E Pereira

❮ Previous
Next ❯

Citations

May 12, 2020·Journal of Alzheimer's Disease : JAD·Víctor AndradeRicardo B Maccioni
Dec 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe TardioloEmanuela Mazzon
Aug 24, 2021·Frontiers in Cell and Developmental Biology·Kai ChenLing-Qiang Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.