Abstract
Following spinal cord trauma, mitochondrial dysfunction associated with increased oxidative stress is a critical event leading to leukocyte inflammatory responses, neuronal cell death and demyelination, contributing to permanent locomotor and neurological disability. The present study demonstrated that the mitochondrial enhancer N-acetylcysteine (NAC) may restore redox balance via enhancement of mitochondrial respiratory activity following traumatic spinal cord injury (SCI). In addition, NAC ameliorates oxidative stress-induced neuronal loss, demyelination, leukocyte infiltration and inflammatory mediator expression and improves long-term locomotor function. Furthermore, neuronal survival and neurological recovery are significantly correlated with increased mitochondrial bioenergetics in SCI following treatment with NAC. Therefore, NAC may represent a potential therapeutic agent for preserving mitochondrial dynamics and integrity following traumatic SCI.
References
Aug 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A ManfridiM Mancia
May 1, 1995·Cardiovascular Research·S A DouglasE H Ohlstein
Mar 11, 2000·The European Journal of Neuroscience·L N NovikovaJ O Kellerth
Jun 8, 2001·Journal of Neurotrauma·J XuC Y Hsu
Jun 19, 2002·Cardiovascular Drug Reviews·Megumu Okada, Masaru Nishikibe
Aug 21, 2004·Journal of Neurotrauma·Jian LuoRiyi Shi
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ning LiAndre E Nel
Apr 27, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Liqun YangMounir N Ghabriel
Jul 26, 2005·British Journal of Plastic Surgery·C-G ZhangA M Hart
Jan 16, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Andrew D H WilsonGiorgio Terenghi
Apr 19, 2007·Journal of Neurotrauma·Melanie L McEwenJoe E Springer
Jun 30, 2007·Journal of Neurotrauma·Patrick G SullivanAlexander G Rabchevsky
Sep 14, 2007·The Cerebellum·Motoki Arakawa, Yoshihisa Ito
Aug 19, 2008·Journal of Neuroscience Research·Samir P PatelAlexander G Rabchevsky
Jan 6, 2009·Journal of Neurotrauma·Haruo KannoEiji Itoi
Jun 27, 2009·Brain Research·Dag WelinLev N Novikov
Oct 14, 2009·FEBS Letters·D GovenM Bonay
Apr 16, 2010·Journal of Neurotrauma·Radhika A VaishnavEdward D Hall
May 5, 2010·Journal of Neurochemistry·Samir P PatelAlexander G Rabchevsky
May 6, 2010·The Journal of Physiology·Liang-Wu FuJohn C Longhurst
Oct 12, 2010·Neuroscience and Biobehavioral Reviews·M BerkG S Malhi
Jun 11, 2011·Journal of Neurotrauma·Sang Mi LeeLinda J Noble-Haeusslein
Jun 29, 2011·Molecular and Cellular Biology·Alvaro Avivar-ValderasJulio A Aguirre-Ghiso
Mar 27, 2012·Neuroscience·S P PatelA G Rabchevsky
Jun 8, 2012·PloS One·Xin YinZhuo-Jing Luo
Jul 17, 2012·Brain : a Journal of Neurology·Jee Y LeeTae Y Yune
Jul 21, 2012·PloS One·Amar KaralijaLev N Novikov
Citations
Jan 24, 2018·Journal of Neurotrauma·Jean-Claude StamegnaFrançois S Roman
Oct 27, 2017·Nanoscale Research Letters·Guang-Yu DuLi-Dong Mi
Mar 21, 2017·Acta Neuropsychiatrica·Kyoko HasebeOlivia M Dean
Oct 21, 2016·Journal of Neurotrauma·Lina DuRobert S B Clark
Mar 6, 2018·Free Radical Research·Feng-Chih ShenPei-Wen Wang
Apr 6, 2017·Scientific Reports·Ji Wei SongZhe Wang
Feb 14, 2018·Molecular Medicine Reports·Jiping NieTiansheng Sun
Aug 8, 2020·Frontiers in Cell and Developmental Biology·Lesang ShenJianmin Zhang
Jan 9, 2021·Journal of Molecular Neuroscience : MN·Qiao ZhengPenghui Li