N-acetylcysteine treats intravenous amiodarone induced liver injury

World Journal of Gastroenterology : WJG
Matthew L MudalelSteven F Solga

Abstract

We report a case of intravenous (IV) amiodarone drug induced liver injury (DILI). The patient received IV N-acetylcysteine (NAC) which resulted in a rapid improvement in liver enzymes. While the specific mechanisms for the pathogenesis of IV amiodarone DILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some commonality. Because IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases.

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Citations

Jul 7, 2017·Clinical Case Reports·Mohammad AnsariAbdalla Yousif
May 13, 2021·Indian Journal of Pharmacology·Recep AlanliOzcan Ozdemir

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