N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Hirofumi IshimuraC Ohyama

Abstract

N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyzes beta1-6 branching of N-acetylglucosamine on asparagine (N)-linked oligosaccharides (N-glycan) of cell proteins. We examined the relationship between GnT-V expression and clinicopathologic features of the patients with bladder cancer. We immunohistochemically examined GnT-V expression in paraffin-embedded bladder cancer specimen using anti-GnT-V monoclonal antibody. We compared GnT-V expression with cause-specific survival of the patients with bladder cancer treated by radical cystectomy. Kaplan-Meier survival curves were generated to show the cause-specific survival. Univariate and multivariate analyses were carried out to compare GnT-V expression with other clinical and pathologic variables. We also evaluated mRNA expression of GnT-V and N-linked oligosaccharide structure in bladder cancer specimens. Immunohistochemistry revealed that GnT-V expression inversely correlated with tumor grade and stage. The incidence of positive GnT-V expression in bladder cancer was significantly higher in low-grade/superficial cancer than in high-grade/invasive cancer. The patients whose tumor was positive for GnT-V survived significantly longer than those whose tumor was nega...Continue Reading

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Citations

Aug 16, 2008·International Journal of Clinical Oncology·Chikara Ohyama
Dec 4, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jia GuoFeng Guan
Apr 28, 2012·Experimental and Molecular Pathology·Ting WeiJian Zhang
Jan 23, 2009·Biochemical and Biophysical Research Communications·Salomé S PinhoCelso A Reis
Jan 24, 2014·TheScientificWorldJournal·Shingo HatakeyamaChikara Ohyama
Sep 8, 2017·International Journal of Molecular Sciences·Julio Cesar M de-Freitas-JuniorSalomé S Pinho
Aug 24, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Mengmeng WangChunfang Gao
Nov 6, 2015·Oncotarget·Julio Cesar Madureira de Freitas Junior, José Andrés Morgado-Díaz
Jan 9, 2014·International Journal of Oncology·Binbin HuangZhirong Wang

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