PMID: 11903748Mar 21, 2002Paper

N-Acetylglucosaminyltransferase V as a possible aid for the evaluation of tumor invasiveness in patients with hepatocellular carcinoma

Journal of Gastroenterology and Hepatology
M YanagiH Asakura

Abstract

A close relationship has been shown to exist between the metastatic potential and beta1-6 branched oligosaccharides in human and rodent cells. N-acetylglucosaminyltransferase V (GnT-V) catalyzes this process. Although this phenomenon has been reported, little is known about the clinical usefulness of the determination of GnT-V in the evaluations of tumor invasiveness in hepatocellular carcinoma (HCC). In this study, we measured the GnT-V activity in serum of patients with HCC, together with its activity and gene expression in HCC tissues, and elucidated the clinical usefulness of the GnT-V level in evaluating tumor invasiveness. Seventy-three serum samples from 38 patients with HCC, 11 with chronic hepatitis, eight with hepatic cirrhosis and 16 healthy controls were used. Twenty-one liver tissues were obtained by surgical resection from 17 patients with HCC, three with colorectal cancers and one with gallbladder cancer metastatic to the liver. The GnT-V activity was determined by using high performance liquid chromatography. The GnT-V mRNA was quantified by using competitive RT-PCR. There were statistically significant correlations between GnT-V activity in sera of HCC, and GnT-V activity and GnT-V mRNA expression in tumor tiss...Continue Reading

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Citations

Dec 19, 2008·Briefings in Functional Genomics & Proteomics·Xin Wei, Lingjun Li
Mar 25, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Tomomi Masuda, Eiji Miyoshi
Apr 6, 2005·Biochemical and Biophysical Research Communications·Mari TomiieYuji Murata
Dec 17, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Koji MiyaharaKazuhide Yamamoto
Jan 23, 2009·Journal of Hepatology·Bram BlommeHans Van Vlierberghe
May 26, 2004·Biochimica Et Biophysica Acta·Susan L Bellis
May 3, 2016·Biomolecules·Yasuhiko Kizuka, Naoyuki Taniguchi
Oct 10, 2012·Journal of Proteome Research·HanJie YuZheng Li
Jun 9, 2006·Molecular & Cellular Proteomics : MCP·Richard R DrakeO John Semmes
Dec 5, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Susumu NakaharaEiji Miyoshi
Nov 4, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yoshihiro KamadaEiji Miyoshi
Jul 26, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Birte SchulenbergWayne F Patton

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