N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Gianluca TosiniP Michael Iuvone

Abstract

N-Acetylserotonin (NAS) is a naturally occurring chemical intermediate in biosynthesis of melatonin. Previous studies have shown that NAS has different brain distribution patterns from those of serotonin and melatonin, suggesting that NAS might have functions other than as a precursor or metabolite of melatonin. Indeed, several studies have now shown that NAS may play an important role in mood regulation and may have antidepressant activity. Additional studies have shown that NAS stimulates proliferation of neuroprogenitor cells and prevents some of the negative effects of sleep deprivation. It is believed that the antidepressant and neurotrophic actions of NAS are due at least in part to the capability on this molecule to activate the TrkB receptor in a brain-derived neurotrophic factor-independent manner. Emerging evidence also indicates that NAS and its derivatives have neuroprotective properties and protect retinal photoreceptor cells from light-induced degeneration. In this review, the authors discuss the literature about this exciting and underappreciated molecule.

References

Apr 1, 1979·Perceptual and Motor Skills·M A Carskadon, W C Dement
Jan 1, 1985·Journal of Neural Transmission·G F OxenkrugC Filipowicz
Dec 15, 1974·Life Sciences·S M PaulA J Mandell
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·S PsarakisG K Smith
Mar 1, 1995·Progress in Neurobiology·J H Benington, H C Heller
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·S Mansour-RobaeyA J Aguayo
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Dec 5, 1998·Brain Research. Molecular Brain Research·P H RoseboomD C Klein
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Jan 22, 2000·Journal of Biological Rhythms·A A Borbély, P Achermann
Jul 27, 2000·The Journal of Biological Chemistry·O NosjeanJ A Boutin
Apr 3, 2001·The International Journal of Neuropsychopharmacology·Irine V. Prakhie, Gregory F. Oxenkrug
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·S GangulyD C Klein
Jul 21, 2001·Seminars in Cell & Developmental Biology·E D Herzog, G Tosini
Jun 6, 2002·Behavioural Brain Research·Dipesh Chaudhury, Christopher S Colwell
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chiaki FukuharaGianluca Tosini
Jan 15, 2005·Sleep Medicine Reviews·Amnon BrzezinskiIan Ford
Apr 27, 2005·Journal of Biological Rhythms·Dipesh ChaudhuryChristopher S Colwell
Jul 15, 2005·Journal of Neurophysiology·Ilana S HairstonH Craig Heller
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Sep 24, 2005·Annals of the New York Academy of Sciences·Gregory Oxenkrug
Nov 3, 2005·The European Journal of Neuroscience·Ruben Guzman-MarinDennis McGinty
Feb 24, 2006·Nature Reviews. Neuroscience·Pierre-Marie LledoMatthew S Grubb
Apr 21, 2006·Brain Research Bulletin·Gigliola Grassi ZucconiRoberto Scattoni
Sep 8, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nikita PozdeyevP Michael Iuvone
Dec 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christian MirescuElizabeth Gould
Feb 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tomi RantamäkiEero Castrén
Jul 17, 2007·Neuroscience·R Guzman-MarinD McGinty
Jun 28, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Luis San, Belen Arranz

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Citations

Sep 3, 2013·International Journal of Molecular Sciences·Shuna YuXin Wang
Sep 11, 2012·Experimental Eye Research·Gianluca TosiniP Michael Iuvone
Aug 13, 2015·Journal of Pineal Research·Charles-Hubert PaulinLaurence Besseau
Jul 12, 2014·Oxidative Medicine and Cellular Longevity·Jiying JiangXin Wang
Aug 30, 2013·Journal of Pharmacological Sciences·Golmaryam SarlakPiyarat Govitrapong
Sep 7, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Clara Herrera-ArozamenaMaría Isabel Rodríguez-Franco
Nov 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annia GalanoRussel J Reiter
Apr 21, 2016·Journal of Biological Rhythms·Joseph C Besharse, Douglas G McMahon
Jun 12, 2018·Journal of Pineal Research·Annia Galano, Russel J Reiter
Jun 25, 2016·The Journal of Biological Chemistry·Brandon WadasAlexander Varshavsky
Aug 11, 2018·Frontiers in Molecular Biosciences·Brian G O'FlynnDavid J Merkler
Jun 26, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Maede RezaieMohammad Ali Nasiri Khalili
Sep 10, 2020·Biomolecules·Eleonora PanfiliMaria Teresa Pallotta
Feb 24, 2019·Journal of Affective Disorders·Andrea AgugliaMario Amore
Sep 10, 2019·Progress in Retinal and Eye Research·Daniela M VerraDavid Hicks
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Karina Juhnevica-RadenkovaVitalijs Radenkovs
Mar 23, 2021·BioMed Research International·Gian Lucas M ArrudaJuliana Mozer Sciani
Mar 24, 2021·Multiple Sclerosis and Related Disorders·Mikhail MelnikovAlexey Boykо
May 3, 2018·Journal of Agricultural and Food Chemistry·Po-Sheng WangWen-Harn Pan

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