N-Acyl Dehydrotyrosines, Tyrosinase Inhibitors from the Marine Bacterium Thalassotalea sp. PP2-459

Journal of Natural Products
Robert W DeeringDavid C Rowley

Abstract

Thalassotalic acids A-C and thalassotalamides A and B are new N-acyl dehydrotyrosine derivatives produced by Thalassotalea sp. PP2-459, a Gram-negative bacterium isolated from a marine bivalve aquaculture facility. The structures were elucidated via a combination of spectroscopic analyses emphasizing two-dimensional NMR and high-resolution mass spectrometric data. Thalassotalic acid A (1) displays in vitro inhibition of the enzyme tyrosinase with an IC50 value (130 μM) that compares favorably to the commercially used control compounds kojic acid (46 μM) and arbutin (100 μM). These are the first natural products reported from a bacterium belonging to the genus Thalassotalea.

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Citations

Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana AlvesMadalena Pinto
Aug 9, 2020·Frontiers in Microbiology·Birthe SandargoFrank Surup
May 19, 2017·Frontiers in Microbiology·Javier DubertJesús L Romalde
Jan 18, 2018·Natural Product Reports·John W BluntMichèle R Prinsep
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury
Mar 26, 2019·Journal of Natural Products·Joseph M SchulzJames D Patrone

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