N-Acylation of Oxazolidinones via Aerobic Oxidative NHC Catalysis

The Journal of Organic Chemistry
Linda TaHenrik Sundén

Abstract

The first N-acylation of synthetically useful oxazolidinones with aldehydes using aerobic oxidative NHC catalysis is reported. The reaction offers a broad scope of functionalized oxazolidinones in good to excellent yields. Careful choice of electron transfer mediators proved pivotal to achieve efficient aerobic N-acylation, which has previously proven difficult using NHC catalysis. The methodology allows a mild entry to acylated oxazolidinones, avoiding the use of hazardous and reactive prefunctionalized substrates.

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Citations

Aug 23, 2020·Materials·Krzysztof DzieszkowskiZbigniew Rafiński
Aug 1, 2021·Chemistry, an Asian Journal·Chandrasekaran Sivaraj, Thirumanavelan Gandhi

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