N-acyliminium intermediates in solid-phase synthesis

Biopolymers
Sebastian T Le QuementThomas E Nielsen

Abstract

N-Acyliminium ions are powerful intermediates in synthetic organic chemistry. Examples of their use are numerous in solution-phase synthesis, but there are unmerited few reports on these highly reactive electrophiles in solid-phase synthesis. The present review covers the literature to date and illustrates the methods used to generate N-acyliminium intermediates on solid support and their further elaboration to a range of pharmacologically interesting peptidomimetics, heterocycles, and other small molecules.

References

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Citations

Apr 16, 2011·The Journal of Organic Chemistry·Nicolas BoutardWilliam D Lubell
Jun 14, 2014·Chemistry : a European Journal·Mette Ishoey, Thomas E Nielsen
Sep 14, 2013·Chemistry, an Asian Journal·Yong Sup LeeRangappa S Keri
May 12, 2017·Chemical Reviews·Peng Wu, Thomas E Nielsen
Sep 6, 2017·Organic & Biomolecular Chemistry·James A Rossi-AshtonWilliam P Unsworth
Apr 6, 2017·Chemical Communications : Chem Comm·Liu-Liang MaoShang-Dong Yang
Jan 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea CalcaterraFrancesca Ghirga
Nov 2, 2017·The Journal of Organic Chemistry·Alessia BertaminoIsabel M Gomez-Monterrey

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