N-acyliminium intermediates in solid-phase synthesis

Sebastian T Le QuementThomas E Nielsen


N-Acyliminium ions are powerful intermediates in synthetic organic chemistry. Examples of their use are numerous in solution-phase synthesis, but there are unmerited few reports on these highly reactive electrophiles in solid-phase synthesis. The present review covers the literature to date and illustrates the methods used to generate N-acyliminium intermediates on solid support and their further elaboration to a range of pharmacologically interesting peptidomimetics, heterocycles, and other small molecules.


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May 22, 2008·Organic Letters·David KesselringKevin D Moeller

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