PMID: 573798Aug 1, 1979

N-Alkyl derivatives of (+/-)-alpha-methyldopamine

Journal of Medicinal Chemistry
J G CannonR J Naylor


A series of N-alkylated alpha-methyldopamine derivatives has been prepared for comparison of their biological effects with those of semirigid dopamine congeners derived from 2-aminotetralin systems. All of the alpha-methyldopamine derivatives were inert as dopaminergic agonists in a variety of animal assays, both centrally and peripherally, although certain compounds produced powerful and prolonged locomotor hyperactivity on intra-accumbens injection in mice, by indirect mechanism(s). A rationalization, based upon conformational analysis, is presented for the lack of direct dopaminergic agonist activity of alpha-methyldopamine derivatives.

Related Concepts

Felis catus
Canis familiaris
Pulse Rate
Myocardial Contraction
Nucleus Accumbens
Stereotyped Behavior

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.