N-Arachidonoyl Dopamine: A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities

Cannabis and Cannabinoid Research
Urszula Grabiec, Faramarz Dehghani

Abstract

N-arachidonoyl dopamine (NADA) is a member of the family of endocannabinoids to which several other N-acyldopamines belong as well. Their activity is mediated through various targets that include cannabinoid receptors or transient receptor potential vanilloid (TRPV)1. Synthesis and degradation of NADA are not yet fully understood. Nonetheless, there is evidence that NADA plays an important role in nociception and inflammation in the central and peripheral nervous system. The TRPV1 receptor, for which NADA is a potent agonist, was shown to be an endogenous transducer of noxious heat. Moreover, it has been demonstrated that NADA exerts protective and antioxidative properties in microglial cell cultures, cortical neurons, and organotypical hippocampal slice cultures. NADA is present in very low concentrations in the brain and is seemingly not involved in activation of the classical pathways. We believe that treatment with exogenous NADA during and after injury might be beneficial. This review summarizes the recent findings on biochemical properties of NADA and other N-acyldopamines and their role in physiological and pathological processes. These findings provide strong evidence that NADA is an effective agent to manage neuroinfla...Continue Reading

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Citations

Nov 2, 2018·Journal of Biochemical and Molecular Toxicology·Rania A A SalamaEzz-El Din S Eldenshary
Aug 2, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Iu A SukhanovaN G Levitskaya
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Jan 5, 2021·Journal of Biochemical and Molecular Toxicology·Shreetama BandyopadhayayaChandi C Mandal
Mar 21, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Astrid Coronado-ÁlvarezEric Murillo-Rodríguez
Apr 3, 2021·The Journal of Pharmacology and Experimental Therapeutics·Nicola L BriceMark B Carlton
Jun 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisAndre F Carvalho
Nov 7, 2021·Neurotoxicity Research·Karen Jaqueline Paredes-RuizAna Laura Colín-González

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Methods Mentioned

BETA
chemical modifications

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