N-Arylamines Coupled with Aldehydes, Ketones, and Imines by Means of Photocatalytic Proton-Coupled Electron Transfer

Chemistry : a European Journal
Qing XiaQingmin Wang

Abstract

A photoredox-catalyzed umpolung strategy for coupling reactions between aldehydes, ketones, imines, and N-arylamines is reported. These reactions proceed by a Brønsted acid-activated proton-coupled electron transfer pathway, and the protocol was used to synthesize a broad scope of 1,2-amino alcohols and vicinal diamines, both of which are common motifs in biologically active natural products, pharmaceutically active molecules, and ligands.

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Citations

Nov 11, 2018·Chemistry : a European Journal·Qing XiaQingmin Wang
Mar 9, 2019·Chemistry : a European Journal·Pilar CallejaThomas Schaub
Sep 13, 2019·Chemical Communications : Chem Comm·Takahiro IwamotoMasaharu Nakamura
Mar 3, 2020·Organic & Biomolecular Chemistry·Filip StanekMaciej Stodulski
Nov 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhenbo YuanYijian Rao
May 12, 2021·Chemical Society Reviews·Áron PéterDavid J Procter
Jun 26, 2021·Chemical Science·Max J Caplin, Daniel J Foley
Sep 15, 2018·Journal of the American Chemical Society·J Luca SchwarzFrank Glorius

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