N-Benzylbenzamides: a new class of potent tyrosinase inhibitors

Bioorganic & Medicinal Chemistry Letters
Sung Jin ChoKi Duk Park

Abstract

A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC(50) of 2.2microM.

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Citations

Oct 12, 2012·Fitoterapia·Xiaofang WuZhiyong Xie
Jul 8, 2009·International Journal of Molecular Sciences·Te-Sheng Chang
Oct 8, 2009·Bioscience, Biotechnology, and Biochemistry·Phebe HendraYasuyuki Hashidoko
Apr 9, 2014·Expert Opinion on Drug Discovery·Eduarda MendesAna Paula Francisco
Feb 17, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Sang Yeul LeeTae-gyu Nam
May 31, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiang FeiSeung-Yong Seo
Apr 17, 2014·The Science of the Total Environment·Larissa DsikowitzkyJan Schwarzbauer
Feb 2, 2021·SAR and QSAR in Environmental Research·Y WuA Yan
Jun 16, 2009·Bioorganic & Medicinal Chemistry Letters·Yoshimitsu YamazakiSusumu Maruyama

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