PMID: 8968186Dec 1, 1996Paper

N-butyl tetracaine as a neurolytic agent for ultralong sciatic nerve block

Anesthesiology
G K WangD C Anthony

Abstract

Neurolytic agents such as phenol (5% to 10%) and absolute alcohol have long been used clinically to destroy the pathogenic nerve regions that manifest pain. Both phenol and alcohol are highly destructive to nerve fibers. However, these agents exert only weak local anesthetic effects and therefore are difficult to administer to alert patients without pain. This report describes a tetracaine derivative that displays both local anesthetic and neurolytic properties. Studies with such a compound may lead to the design of neurolytic agents that are more effective and more easily administered than phenol and alcohol. A tetracaine derivative, N-butyl tetracaine quaternary ammonium bromide, was synthesized, and its ability to elicit sciatic nerve block of sensory and motor functions in vivo was tested in rats. A single dose of 0.1 ml N-butyl tetracaine at 37 mM was injected into the sciatic notch. Transverse sections of treated sciatic nerves were subsequently examined to determine the neurolytic effect of this drug. Finally, the local anesthetic properties of N-butyl tetracaine were studied in vitro; both tonic inhibition and use-dependent inhibition of Na+ currents in neuronal GH3 cells were characterized under whole-cell voltage-clam...Continue Reading

References

Mar 1, 1976·The Journal of General Physiology·B Hille, D T Campbell
Apr 1, 1990·Anesthesiology·J F Butterworth, G R Strichartz
Aug 1, 1989·The Journal of General Physiology·G Cota, C M Armstrong
Jul 1, 1973·The Journal of General Physiology·G R Strichartz
Sep 1, 1983·Journal of Neuropathology and Experimental Neurology·D C AnthonyD G Graham
Apr 1, 1995·Anesthesiology·J G ThalhammerG R Strichartz

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Citations

Feb 25, 2005·Anesthesia and Analgesia·Igor KissinEdwin L Bradley
Apr 14, 2010·Anaesthesia·M D Wiles, M H Nathanson
Sep 23, 2014·Biochemical and Biophysical Research Communications·Rathej MeerupallyShyam S Sharma
Aug 10, 2002·Anesthesiology·Peter GernerGing Kuo Wang
Aug 27, 2004·Anesthesiology·Igor Kissin, Sandra S Lee
Aug 24, 2018·Frontiers in Molecular Neuroscience·Raúl CoboAndrés Morales
Feb 28, 2002·Anesthesia and Analgesia·Robert J McCarthyAnthony D Ivankovich
Sep 5, 2017·World Journal of Clinical Cases·Amlan SwainDevi Prasad Samaddar

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