N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice

Diabetes, Obesity & Metabolism
D A PriestmanFrances M Platt

Abstract

To determine the mechanism of weight loss caused by high doses of N-butyldeoxynojirimycin (NB-DNJ) in healthy lean and leptin-deficient obese (ob/ob) mice. Healthy lean and obese mice were treated with NB-DNJ by the following methods: admixed with their diet, delivered by subcutaneously implanted mini-pumps or by intraperitoneal or intracerebroventricular (ICV) injection. Daily changes in body weight and food intake were recorded during the experimental period. The effect of NB-DNJ treatment on subcutaneous adipose tissue and on epididymal fat pads was measured. Lean mice treated with NB-DNJ, admixed with their diet, lost weight in the form of adipose tissue. This resulted in a 40% reduction in skin thickness (control, 358 +/- 11 microm; NB-DNJ treated 203 +/- 6 microm) and a reduction in epididymal fat pad weights after 5 weeks of treatment at 2400 mg/kg/day (control, 0.0154 +/- 0.001; NB-DNJ treated, 0.0026 +/- 0.0005 as ratios of fat pad weight to total body weight). Following the depletion of adipose tissue mass, the mice grew normally and did not have any reduction in lean mass. Obese mice treated with NB-DNJ also lost weight or gained weight at a greatly reduced rate compared with non-treated controls. Body weights at 6 m...Continue Reading

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Citations

May 8, 2013·Molecular Nutrition & Food Research·Khem B AdhikariInge S Fomsgaard
Jun 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdullahi AliyuHazilawati Hamzah
Oct 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Izumi NakagomeShuichi Hirono

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