PMID: 8946049Nov 22, 1996Paper

N-cadherin expression and function in cultured oligodendrocytes

Brain Research. Developmental Brain Research
H R PayneV Lemmon

Abstract

N-Cadherin is a major cell adhesion molecule that is expressed in the developing nervous system where it has been implicated in neural migration and axon growth. Recently, a role for N-cadherin in oligodendrocyte differentiation has been identified [23]. Oligodendrocyte precursors adhere to N-cadherin and mature rapidly to produce myelin sheets. Since this implies that oligodendrocytes express N-cadherin, we examined the expression of N-cadherin by oligodendrocytes in culture. N-Cadherin was expressed by O-2A progenitors, immature oligodendrocytes and mature oligodendrocytes, but at a lower level than in type 1 astrocytes in the same cultures. On mature oligodendrocytes, the N-cadherin was concentrated on the major processes emerging from the soma. The ability of N-cadherin and merosin to promote oligodendrocyte precursor migration was also studied. Average migration rates were significantly higher on merosin (11.2 microns/h) than on N-cadherin (5.6 microns/h). These results suggest that N-cadherin is not likely to function predominantly as a substrate that stimulates migration of O-2A progenitors, but may be more important in initiating early oligodendrocyte-axon interactions that promote the process of myelination.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J E Bottenstein, G H Sato
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G S EisenbarthM Nirenberg
May 1, 1991·Differentiation; Research in Biological Diversity·L A Lagunowich, G B Grunwald
Oct 11, 1990·Nucleic Acids Research·R A Reid, J J Hemperly
Apr 1, 1990·The Journal of Cell Biology·J L Bixby, R Zhang
Dec 1, 1988·Developmental Biology·L LandmesserU Rutishauser
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C Lagenaur, V Lemmon
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B RanschtW Seifert
Jun 1, 1993·Trends in Cell Biology·S E PfeifferR Bansal

❮ Previous
Next ❯

Citations

Aug 1, 1997·Molecular Neurobiology·R J Colello, U Pott
Aug 23, 2005·Brain Research. Brain Research Reviews·Fernando de Castro, Ana Bribián
Apr 25, 2000·Progress in Neurobiology·C Redies
Jan 30, 2002·Pediatric Neurology·H Jacobus GilhuisFons J M Gabreëls
May 15, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michael HarzheimStephan Schmidt
Feb 3, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michael HarzheimStephan Schmidt
Dec 6, 2007·Australasian Radiology·J K Ibrahim AbdullaS Abubacker
May 16, 1998·The Journal of Cell Biology·S M Brady-KalnayN K Tonks
Sep 25, 2004·The Journal of Comparative Neurology·Norbert ChauvetMonica Prieto
Sep 25, 2008·Developmental Neurobiology·Ana BribiánFernando de Castro
Jul 14, 2010·Journal of Neuroscience Research·Mikael CorellÅsa Fex Svenningsen
Jun 21, 2001·Molecular and Cellular Neurosciences·O SchnädelbachJ W Fawcett
Oct 27, 2001·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·S DolapchievaW Kühnel
Mar 29, 2000·Molecular and Cellular Neurosciences·O SchnädelbachJ W Fawcett
Apr 8, 1998·Annual Review of Neuroscience·H KamiguchiV Lemmon
Sep 17, 2013·Neuroscience·R G Almeida, D A Lyons
Aug 6, 1999·Molecular and Cellular Neurosciences·M J WilbyJ W Fawcett
Dec 11, 1999·Current Opinion in Pediatrics·M H Lequin, A J Barkovich
Aug 28, 2020·Frontiers in Cellular Neuroscience·Daniela Espinosa-HoyosKrystyn J Van Vliet
Dec 16, 2019·Neuroscience Letters·Ekta P MakhijaKrystyn J Van Vliet
Nov 14, 2021·Glia·Minkyung Kang, Yao Yao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.