PMID: 9177902Mar 1, 1997Paper

N-cadherin promotes adhesion between invasive breast cancer cells and the stroma

Cell Adhesion and Communication
R B HazanP I Borgen

Abstract

Calcium-dependent cell adhesion molecules (cadherins) are involved in maintaining the epithelial structure of a number of tissues including the mammary gland. In breast and other tumor types, loss of E-cadherin expression has been seen in high grade tumors and correlates with increased invasiveness. Here we show high levels of expression of N-cadherin in the most invasive breast cancer cell lines which was inversely correlated with their expression of E-cadherin. A stromal cell line also expressed N-cadherin in accordance with its fibroblastic morphology. N-cadherin localized to areas of cell-cell contact in all cells that expressed it. Calcium-dependent intercellular adhesion of N-cadherin-expressing breast cancer and stromal cells was specifically inhibited by an anti N-cadherin monoclonal antibody. In addition, N-cadherin promoted the interaction of invasive breast cancer cells with mammary stromal cells; in contrast, E-cadherin expressing cell lines did not co-aggregate with stromal cells. The combined results suggest a functional role for N-cadherin in cohesion of breast tumor cells which, in addition promotes their interaction with the surrounding stromal cells, thereby facilitating invasion and metastasis.

References

Jan 1, 1992·Annual Review of Cell Biology·B Geiger, O Ayalon
Apr 1, 1991·The Journal of Cell Biology·U H FrixenW Birchmeier
Apr 1, 1987·Molecular and Cellular Biology·S L Warren, W J Nelson
May 1, 1987·The Journal of Cell Biology·J L DubandJ P Thiery
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K HattaM Takeichi
Nov 1, 1985·Developmental Biology·D VestweberP Ekblom
Sep 1, 1995·British Journal of Cancer·N ShinouraS Hirohashi
Jan 1, 1994·Breast Cancer Research and Treatment·C L SommersE P Gelmann
Mar 1, 1994·Developmental Biology·A P Soler, K A Knudsen

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Citations

Jun 15, 2007·Journal of Mammary Gland Biology and Neoplasia·Georgia AgiostratidouRachel B Hazan
May 10, 2001·Cancer Genetics and Cytogenetics·I J ChalmersM J Atkinson
Nov 10, 2000·Advanced Drug Delivery Reviews·R J Parkes, S L Hart
Mar 31, 2000·Molecular Medicine Today·G Li, M Herlyn
Oct 13, 2012·The Journal of Biological Chemistry·Zoi DiamantopoulouPanagiotis Katsoris
Nov 30, 2005·Nucleic Acids Research·Cindy VandewalleGeert Berx
Feb 27, 2001·Current Opinion in Oncology·C Gruss, M Herlyn
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C HagiosM J Bissell
Feb 26, 2010·Cold Spring Harbor Perspectives in Biology·Julian Heuberger, Walter Birchmeier
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Geert Berx, Frans van Roy
Jan 5, 2012·Cold Spring Harbor Perspectives in Biology·Eduard Batlle, David G Wilkinson
Mar 20, 1998·American Journal of Reproductive Immunology : AJRI·C D MacCalmanG T Chen
Sep 30, 2009·Molecular and Cellular Biology·Nikia LaurieMichael A Dyer
Mar 1, 2000·Molecular Pathology : MP·V M Braga
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Margaret J Wheelock, Keith R Johnson
Aug 4, 2007·American Journal of Respiratory Cell and Molecular Biology·Yasushi ShintaniMargaret J Wheelock
Jan 9, 2004·Reproductive Biology and Endocrinology : RB&E·Delisha A StewartRobert A Sikes
Nov 15, 2011·Breast Cancer Research : BCR·David J DrasinHeide L Ford
Feb 10, 2012·Breast Cancer Research : BCR·Jennifer L AndrewsJulie R Hens
Sep 29, 2012·Current Pharmaceutical Design·Andrey Voronkov, Stefan Krauss
Feb 18, 2009·World Journal of Gastroenterology : WJG·Ke LiQing-Xia Fan
Oct 10, 2006·Clinical & Experimental Metastasis·L DeryckeE Van Aken
Dec 26, 2015·International Journal of Environmental Research and Public Health·Patrick P CarriereSyreeta L Tilghman
Dec 20, 2011·Cell Communication & Adhesion·Andrea Buda, Massimo Pignatelli
Jul 31, 1999·Cell Adhesion and Communication·L Van HoordeM Mareel
Jan 31, 2016·Small GTPases·Jaap D van Buul, Ilse Timmerman
Apr 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Satoshi KudoYoshihiro Minamiya
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Erika RosivatzKarl-Friedrich Becker
May 11, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ira SkvortsovaPeter Lukas
Oct 20, 2009·European Journal of Pharmacology·Orest W Blaschuk, Emmanuelle Devemy
Jul 8, 2003·The Journal of Pathology·Olivier De Wever, Marc Mareel

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