N-cadherin promotes the commitment and differentiation of skeletal muscle precursor cells

Developmental Biology
Mindy George-WeinsteinK A Knudsen

Abstract

Cells with the potential to form skeletal muscle are present in the chick embryo prior to gastrulation. Muscle differentiation begins after gastrulation within the somites. The role of cadherin-mediated adhesion in the commitment and differentiation of skeletal muscle precursor cells was examined by analyzing the expression of cell-cell adhesion molecules in cultures of epiblast, segmental plate, and somite cells and by determining the effects of adhesion-perturbing antibodies on the accumulation of MyoD and sarcomeric myosin. Cultured primitive streak stage epiblast cells downregulate E-cadherin and upregulate N-cadherin. This switch in cadherin expression also occurs in vivo as epiblast cells enter the primitive streak. Although MyoD protein is present in cells with N- or E-cadherin, only cells with N-cadherin differentiate into skeletal muscle. In contrast to the primitive streak stage epiblast cells, prestreak epiblast cells maintain the expression of E-cadherin in vitro. While the majority of prestreak cells contain MyoD, only a few synthesize myosin. Treatment of primitive streak stage epiblast cells with function-perturbing antibodies to N-cadherin resulted in an inhibition of myosin accumulation and a decrease in the pe...Continue Reading

References

Feb 1, 1991·Differentiation; Research in Biological Diversity·M J Wheelock, K A Knudsen
Oct 1, 1990·Current Opinion in Cell Biology·K A Knudsen
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M OzawaR Kemler
Jan 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T S Okada
Dec 22, 1988·Nature·J B Gurdon
Jan 1, 1986·Anatomy and Embryology·R Bellairs
May 1, 1987·The Journal of Cell Biology·J L DubandJ P Thiery
Sep 1, 1986·Developmental Biology·E Vivarelli, G Cossu
Dec 1, 1982·The Journal of Cell Biology·D BaderD A Fischman
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W J GallinB A Cunningham
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G M EdelmanJ P Thiery
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L RimmJ S Morrow
May 1, 1995·Anatomy and Embryology·B Christ, C P Ordahl
Mar 24, 1995·Cell·C E LindsellG Weinmaster
Jan 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F MyokaiT Saito
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·T S JouJ A Marrs
Dec 1, 1994·Developmental Biology·J Klingensmith, R Nusse
Jan 1, 1995·Developmental Biology·H M Stern, S D Hauschka
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·G CossuM Buckingham
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C E HoltJ B Gurdon
Mar 1, 1994·Developmental Biology·A P Soler, K A Knudsen
Apr 1, 1994·Experimental Cell Research·M George-WeinsteinJ W Lash
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·S Tajbakhsh, M E Buckingham
Aug 1, 1993·Experimental Cell Research·K R JohnsonM J Wheelock
Oct 1, 1995·Current Opinion in Cell Biology·B M Gumbiner
Jan 10, 1996·Developmental Biology·M George-WeinsteinH Weintraub

❮ Previous
Next ❯

Citations

Feb 7, 1998·Cell Motility and the Cytoskeleton·K Imanaka-YoshidaK K Linask
Dec 11, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H YajimaH Ide
Mar 21, 2000·Journal of Cellular Biochemistry·M R SeghatoleslamiK A Knudsen
Nov 21, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D R CanningE Richard
Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Janice L WalkerA Sue Menko
Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Haley W SinnJim J-C Lin
Sep 13, 2006·Anatomy and Embryology·Chaya KalcheimRaz Ben-Yair
Mar 21, 2003·Developmental Biology·Duke DuguayMalcolm S Steinberg
Dec 26, 2002·Biology of the Cell·Véronique MarthiensRené Marc Mège
Jan 10, 2002·Biochimica Et Biophysica Acta·U Cavallaro, G Christofori
Oct 2, 2003·Current Opinion in Cell Biology·Margaret J Wheelock, Keith R Johnson
Oct 6, 1999·Current Opinion in Cell Biology·M S Steinberg, P M McNutt
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Min Lu, Robert S Krauss
Feb 24, 2011·Molecular & Cellular Proteomics : MCP·C Y X'avia ChanK W Michael Siu
Aug 7, 2009·Molecular & Cellular Proteomics : MCP·Rebekah L GundryBernd Wollscheid
Nov 5, 1998·Molecular Biology of the Cell·P Goichberg, B Geiger
Jan 14, 2005·Molecular Biology of the Cell·Graziella MessinaMilena Grossi
May 26, 1998·Annals of the New York Academy of Sciences·M George-WeinsteinK Knudsen
Apr 28, 2007·Annual Review of Biomedical Engineering·Paul A Janmey, Christopher A McCulloch
Nov 8, 2008·Acta Histochemica Et Cytochemica·Atsushi SakamotoMotoshi Kikuchi
Mar 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jong-Sun KangRobert S Krauss
Nov 16, 2011·International Journal of Proteomics·C Y X'avia ChanK W Michael Siu
Mar 15, 2013·American Journal of Physiology. Cell Physiology·Han-Zhong FengJ-P Jin
Sep 23, 1997·The Journal of Cell Biology·A RedfieldK A Knudsen
Oct 24, 1998·The Journal of Cell Biology·J S KangR S Krauss
May 23, 1998·The Journal of Cell Biology·A HuttenlocherA F Horwitz
Feb 26, 2004·The Journal of Cell Biology·Jacquelyn GerhartMindy George-Weinstein
Mar 21, 2007·Expert Opinion on Investigational Drugs·Agnese MariottiCurzio Rüegg
May 17, 2000·The Journal of Cell Biology·J GerhartM George-Weinstein
Sep 6, 2002·The Journal of Cell Biology·Sophie CharrasseCécile Gauthier-Rouvière
Nov 8, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Pierre-Yves RescanVeronique Lebret
Sep 21, 2011·Journal of Tissue Engineering and Regenerative Medicine·Zahia BayoussefKevin M Shakesheff
Sep 17, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Tamara A CollElisa Cebral
Jan 22, 2005·Gene Expression Patterns : GEP·Robert StronyMindy George-Weinstein
Jul 4, 2006·The American Journal of Pathology·Yeong-Hoon ChoiDouglas B Cowan
Mar 26, 2010·The Biochemical Journal·Sheng Pin Hsiao, Shen Liang Chen
Nov 26, 2009·Developmental Biology·Kate RochlinMary K Baylies
Jul 22, 2010·Cell Cycle·Min Lu, Robert S Krauss
Jun 6, 2000·Current Biology : CB·B KnightA R Horwitz

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