N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model

Biochimie
Yeong-Gon Choi, Sabina Lim

Abstract

This study investigated the involvement of advanced glycation end products (AGEs) that may be nonenzymatically linked to α-synuclein accumulation in the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced C57BL/6 mouse model of parkinsonism. MPTP (20 mg/kg) was intraperitoneally administrated once daily for 30 days to the MPTP group while a saline only solution was administered to the control group. Results show that the immunoreactivities of the tyrosine hydroxylase and dopamine transporter significantly decreased in the striatum and the substantia nigra (SN) in the MPTP model compared to the subjects in the control group. α-synuclein was co-localized with N(ɛ)-(carboxymethyl)lysine (CML) and N(ɛ)-(carboxyethyl)lysine (CEL), which are well-known AGEs, in tyrosine hydroxylase-positive dopaminergic neurons in the MPTP brains. α-synuclein was also shown to be deposited in the CD11b-positive activated microglia. Some AGEs-modified proteins (CML-, CEL-, pentosidine-, or pyrraline-modified proteins) and an oligomeric form of α-synuclein appear to have almost the same molecular weight, specifically between 50 and 75 kDa; in addition, these formations were more strongly deposited in the SN region of the MPTP brains tha...Continue Reading

References

May 1, 1991·Neurology·D A Di Monte
May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Mar 23, 1995·Nature·M A SmithG Perry
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·M P VitekA Cerami
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Nov 5, 1997·Neuroscience Letters·E BezardC E Gross
Aug 10, 2000·The American Journal of Pathology·L J HsuE Masliah
Mar 10, 2001·Recent Progress in Hormone Research·P Ulrich, A Cerami
Jan 5, 2002·Journal of Neural Transmission·N Schmidt, B Ferger
Jul 12, 2002·Journal of Neuroscience Research·Yong B LeeSeung U Kim
Oct 22, 2003·Archives of Biochemistry and Biophysics·Vincent M Monnier
Dec 4, 2003·Biochemical Society Transactions·R NagaiY Unno
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Feb 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Clifford W Shults
Sep 3, 2008·Journal of Neurochemistry·Daniel Alvarez-FischerPatrick P Michel
Dec 24, 2008·Biochimica Et Biophysica Acta·Daekyun LeeKwan Yong Choi
Feb 28, 2009·The European Journal of Neuroscience·Nicoletta SchintuAnna R Carta
Oct 24, 2009·Neurochemistry International·Bae Dong JungHyoung-Chun Kim

❮ Previous
Next ❯

Citations

Apr 20, 2014·Ageing Research Reviews·F RocaE Boulanger
Dec 23, 2015·Ageing Research Reviews·Nicoletta Plotegher, Luigi Bubacco
Mar 8, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Hugo Vicente MirandaTiago Fleming Outeiro
Mar 29, 2013·Journal of Neurochemistry·Hugo Vicente MirandaTiago F Outeiro
Feb 27, 2018·Journal of Parkinson's Disease·Annekatrin KönigTiago Fleming Outeiro
Apr 11, 2019·The American Journal of Chinese Medicine·Sujung Yeo, Sabina Lim
Feb 11, 2021·International Journal of Molecular Sciences·David SeynnaeveVanessa Franssens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.