PMID: 39134Jun 1, 1979

N-Chloroacetyl 5-methoxytryptamine (isamide): a selective antagonist of 5-hydroxytryptamine in the rat uterus

The Journal of Pharmacy and Pharmacology
J P Huidobro-ToroM Ruiz

Abstract

Isamide, the N-chloroacetyl derivative of 5-methoxytryptamine, produced a dose-dependent competitive blockade of uterine contractions in vitro induced by 5-HT. The pA2 value for the 5-HT-isamide interaction was 4.42. The blockade was short-lasting and reversible; after recovery, a dose-dependent increase in the uterine sensitivity to 5-HT was found. The blockade proved to be selective to the 5-HT receptor. The simultaneous application of 5-HT plus isamide partially prevented the 5-HT-induced auto blockade phenomenon. In addition, isamide did not affect the contractile responses of the uterus to oxytocin or bradykinin or the contractile effects of the rat vas deferens to adrenaline.

References

Mar 22, 1976·Biochemical and Biophysical Research Communications·D Atlas, A Levitzki
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·B B WolfeP B Molinoff
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D AtlasA Levitzki
Nov 1, 1976·The American Journal of Physiology·J RobleroE De Vito
Jan 1, 1970·Annual Review of Pharmacology·B R Baker
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

Related Concepts

5-Methoxytryptamine
Inotropism
Smooth Muscle
Hydroxytryptamine
Serotonin Antagonists
Triptans
Uterine Contraction
Vas Deferens Structure

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