PMID: 6168845Sep 1, 1981Paper

N"-Cyano-N-4-pyridyl-N'-1,2,2-trimethyl-propylguanidine, a new vasodilating agent: acute effect of blood pressure and pharmacokinetics in hypertensive patients

Journal of Cardiovascular Pharmacology
T KardelJ Trap-Jensen

Abstract

N"-Cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine (P 1134) is a new vasodilating antihypertensive compound. In an open study, P 1134 was given in single oral doses of from 10 to 25 mg to 12 previously untreated patients with essential hypertension. All patients responded with decreases in mean arterial pressure (MAP) of at least 10 mm Hg and with almost equal blood pressure decreases in the supine and erect position. The increase of dose was significantly correlated with a progressive reduction of blood pressure. At a dose of 25 mg, the maximal decrease in supine MAP averaged 38 mm Hg, and the maximal increase in heart rate averaged 23 beats/min. Peak effect and serum concentration were seen about 1 h after tablet intake. The serum half-life from the peak concentration averaged 2.5 h. It is concluded that P 1134 is a fast-acting, effective antihypertensive agent.

Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·K KoliopoulosN B Karatzas
Jan 1, 1985·European Journal of Clinical Pharmacology·V D'ArcyM P Hickey
Jan 1, 1984·European Journal of Clinical Pharmacology·J W WardP Sharp
Jan 1, 1985·European Journal of Clinical Pharmacology·G MuiesanO E Christensen
Jan 1, 1988·European Journal of Clinical Pharmacology·A McBurneyJ W Ward
Nov 20, 1990·European Journal of Pharmacology·G J GroverP G Sleph
Aug 1, 1985·Prostaglandins, Leukotrienes, and Medicine·R P GoodmanJ T Wright
Nov 15, 2000·Bioorganic & Medicinal Chemistry Letters·K YoshiizumiH Kondo
Jan 1, 1991·British Journal of Clinical Pharmacology·C ThuillezJ F Giudicelli
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·M P Cinquegrani, C S Liang
Apr 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K Sakamoto, Y Nakamura
Jun 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K Sakamoto, Y Nakamura
Apr 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K Sakamoto, Y Nakamura
Jan 1, 1992·Critical Reviews in Toxicology·P DogteromG K Reznik
Aug 1, 1985·British Journal of Clinical Pharmacology·M P CaruanaE B Raftery
Mar 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E EilertsenE Arrigoni-Martelli
Nov 1, 1982·Acta Pharmacologica Et Toxicologica·E Mikkelsen, O L Pedersen
Sep 1, 1986·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Jan 1, 1985·The Journal of International Medical Research·M S Laher, M P Hickey
Jul 1, 1987·Journal of Clinical Pharmacology·M C Rijk, T Thien

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.