PMID: 44446Nov 1, 1979

N-demethylation of lergotrile by Streptomyces platensis

Applied and Environmental Microbiology
P J DavisR V Smith

Abstract

Thirty-eight microorganisms were screened for their ability to produce metabolites of the semisynthetic alkaloid, lergotrile. A total of five microorganisms were found to biotransform lergotrile, and N-desmethyl lergotrile was detected as the principal metabolite with most organisms. Streptomyces platensis (NRRL 2364) appeared to form the metabolite in highest yield, and a preparative-scale conversion was accomplished with a recovered yield of 50%. Structure proof was accomplished with comparative thin-layer chromatography, mixed melting point, mass spectrometry, and remethylation to lergotrile.

References

Oct 1, 1985·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P J Davis, L E Guenthner
Apr 1, 1985·Medicinal Research Reviews·A M ClarkC D Hufford

Related Concepts

N-desmethyl lergotrile
Filamentous fungus
Fermentation
Ergoline
Metabolic Biotransformation
Streptomyces

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