N-Docosahexaenoylethanolamide promotes development of hippocampal neurons

The Biochemical Journal
Hee-Yong KimBill X Huang

Abstract

DHA (docosahexaenoic acid, C22:6,n-3) has been shown to promote neurite growth and synaptogenesis in embryonic hippocampal neurons, supporting the importance of DHA known for hippocampus-related learning and memory function. In the present study, we demonstrate that DHA metabolism to DEA (N-docosahexaenoylethanolamide) is a significant mechanism for hippocampal neuronal development, contributing to synaptic function. We found that a fatty acid amide hydrolase inhibitor URB597 potentiates DHA-induced neurite growth, synaptogenesis and synaptic protein expression. Active metabolism of DHA to DEA was observed in embryonic day 18 hippocampal neuronal cultures, which was increased further by URB597. Synthetic DEA promoted hippocampal neurite growth and synaptogenesis at substantially lower concentrations in comparison with DHA. DEA-treated neurons increased the expression of synapsins and glutamate receptor subunits and exhibited enhanced glutamatergic synaptic activity, as was the case for DHA. The DEA level in mouse fetal hippocampi was altered according to the maternal dietary supply of n-3 fatty acids, suggesting that DEA formation is a relevant in vivo process responding to the DHA status. In conclusion, DHA metabolism to DEA i...Continue Reading

References

Feb 28, 1997·Journal of Medicinal Chemistry·T SheskinR Mechoulam
Jan 5, 2000·Biophysical Journal·Y E KorchevC R Edwards
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·A BergerV Di Marzo
Jul 5, 2003·Physiological Reviews·Tamas F FreundDaniele Piomelli
Jun 11, 2004·Journal of Neurochemistry·Zhiming Wen, Hee-Yong Kim
Aug 4, 2004·Journal of Neurochemistry·Frances Calderon, Hee-Yong Kim
Jan 25, 2005·Bioorganic & Medicinal Chemistry Letters·Keiko YamamotoSachiko Yamada
Jul 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mohammed AkbarHee-Yong Kim
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jie LiuGeorge Kunos
Feb 8, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Nicolas G Bazan
Oct 25, 2007·Journal of Lipid Research·Giuseppe AstaritaDaniele Piomelli
Nov 27, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Frances Calderon, Hee-Yong Kim
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chengwei HeJing X Kang
Jul 9, 2009·Journal of Lipid Research·Bo TanJ Michael Walker
Aug 18, 2009·Journal of Neurochemistry·Dehua CaoHee-Yong Kim

❮ Previous
Next ❯

Citations

Jul 16, 2011·The Journal of Biological Chemistry·Rong YangCharles N Serhan
Nov 20, 2013·Neuroscience and Biobehavioral Reviews·Keith A FeigensonSteven M Silverstein
Jun 9, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C JoffreS Laye
Oct 24, 2015·Proceedings of the National Academy of Sciences of the United States of America·Katarzyna MalenczykTibor Harkany
Aug 4, 2011·Prostaglandins & Other Lipid Mediators·Hee-Yong KimZheng-Mei Xiong
May 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jean-Christophe DelpechSophie Layé
Jul 25, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bombi LeeDae-Hyun Hahm
May 11, 2015·The Journal of Pain : Official Journal of the American Pain Society·Christopher E RamsdenJoseph R Hibbeln
Sep 11, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hee-Yong Kim, Arthur A Spector
Aug 3, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Christine HeberdenMonique Lavialle
Jul 19, 2016·Advances in Pediatrics·Susan E Carlson, John Colombo
Feb 7, 2017·Healthcare·Amy ParekhSandrine Thure
Oct 24, 2014·Journal of Lipid Research·Arthur A Spector, Hee-Yong Kim
Sep 27, 2013·The American Journal of Clinical Nutrition·Colin D SteerJoseph R Hibbeln
Oct 28, 2018·The European Journal of Neuroscience·Sanjay AryalSvend Davanger
Mar 1, 2012·Biomolecules & Therapeutics·Kazuhiro TanakaWei-Yi Ong
Dec 29, 2015·Current Opinion in Lipidology·Shoug M AlashmaliRichard P Bazinet
Jun 7, 2019·Annals of the New York Academy of Sciences·Rory K MorganAmit Mogha
Apr 1, 2020·International Journal of Molecular Sciences·Cinzia GiordanoDaniela Bonofiglio
Apr 18, 2020·The Proceedings of the Nutrition Society·Mathieu Di MiceliSophie Layé
Aug 28, 2020·European Journal of Pain : EJP·Kelly F PatonBronwyn M Kivell
Sep 15, 2018·Nutrients·Adriana V GaitánCarol J Lammi-Keefe
Aug 8, 2013·Journal of Neurochemistry·Sarah K OrrRichard P Bazinet
Mar 25, 2020·International Journal of Molecular Sciences·Luana da Silva ChagasClaudio A Serfaty
Feb 12, 2021·Journal of Neuroimmunology·Durga Shankar SharmaRavi Kumar Gutti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.