PMID: 9182719Jun 1, 1997Paper

N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

The Biochemical Journal
M U AhmedJ W Baynes

Abstract

Advanced glycation end-products and glycoxidation products, such as Nepsilon-(carboxymethyl)lysine (CML) and pentosidine, accumulate in long-lived tissue proteins with age and are implicated in the aging of tissue proteins and in the development of pathology in diabetes, atherosclerosis and other diseases. In this paper we describe a new advanced glycation end-product, Nepsilon-(carboxyethyl)lysine (CEL), which is formed during the reaction of methylglyoxal with lysine residues in model compounds and in the proteins RNase and collagen. CEL was also detected in human lens proteins at a concentration similar to that of CML, and increased with age in parallel with the concentration of CML. Although CEL was formed in highest yields during the reaction of methylglyoxal and triose phosphates with lysine and protein, it was also formed in reactions of pentoses, ascorbate and other sugars with lysine and RNase. We propose that levels of CML and CEL and their ratio to one another in tissue proteins and in urine will provide an index of glyoxal and methylglyoxal concentrations in tissues, alterations in glutathione homoeostasis and dicarbonyl metabolism in disease, and sources of advanced glycation end-products in tissue proteins in agin...Continue Reading

Citations

Mar 22, 2003·Journal of Cataract and Refractive Surgery·Sybille FrankeJürgen Strobel
Apr 27, 2005·Hypertension·Miranda T SchramUNKNOWN EURODIAB Prospective Complications Study Group
Jul 23, 2005·Annals of the New York Academy of Sciences·Ryoji NagaiJohn W Baynes
Aug 9, 2005·The Journal of Peptide Research : Official Journal of the American Peptide Society·P Gruber, T Hofmann
Jun 15, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Josephine V GlennAlan W Stitt
Jun 24, 2008·Protein Science : a Publication of the Protein Society·Takumi TakataKirsten J Lampi
May 27, 2009·International Journal of Molecular Sciences·Ming-Shu Hsieh, Wen-Hsiung Chan
Nov 13, 2008·Cytotechnology·Sarocha Kingkeohoi, Frank W R Chaplen
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Kaushik M DesaiLingyun Wu
Nov 16, 2010·Journal of Pharmacological Sciences·Masashi MukohdaYukio Hara
Aug 26, 2011·The British Journal of Nutrition·P MuthennaG Bhanuprakash Reddy
Jun 3, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Caatje Y le PooleCasper G Schalkwijk
Sep 18, 2012·Endocrine·Paulo MatafomeRaquel Seiça
Mar 19, 2013·Amino Acids·Ryoji NagaiMime Nagai
Apr 9, 2013·Electrophoresis·Statis PataridisIvan Mikšík
Mar 8, 2013·Dermato-endocrinology·Paraskevi Gkogkolou, Markus Böhm
Jul 22, 2014·Angewandte Chemie·Michael Hellwig, Thomas Henle
Mar 31, 2015·Clinical Science·Dionne E M MaessenCasper G Schalkwijk
Mar 8, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Hugo Vicente MirandaTiago Fleming Outeiro
Oct 10, 2015·Scientific Reports·Siao-Syun GuanShing-Hwa Liu
Sep 25, 2017·Journal of Biomolecular Structure & Dynamics·Mohd Adnan KhanKhursheed Alam
Nov 29, 2017·International Journal of Molecular Sciences·Alena SobolevaAndrej Frolov
Feb 1, 2018·International Journal of Molecular Sciences·Cinzia Antognelli, Vincenzo Nicola Talesa
Jul 6, 2018·PloS One·Sergio Salazar-VillaneaAntonius F B van der Poel
May 22, 2019·Obesity·José C E SerranoManuel Portero-Otín
Mar 19, 2020·International Journal of Molecular Sciences·Masashi TanakaMasafumi Ihara

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