PMID: 9450345Feb 5, 1998Paper

N-glycans harboring the Lewis a epitope are expressed at the surface of plant cells

The Plant Journal : for Cell and Molecular Biology
A C Fitchette-LainéLoïc Faye

Abstract

In plants, N-linked glycans are processed in the Golgi apparatus to complex-type N-glycans of limited size containing a beta(1,2)-xylose and/or an alpha(1,3)-fucose residue. Larger mono- and bi-antennary N-linked complex glycans have not often been described. This study has re-examined the structure of such plant N-linked glycans, and, through both immunological and structural data, it is shown that the antennae are composed of Lewis a (Le(a)) antigens, comprising the carbohydrate sequence Gal beta 1-3[Fuc alpha 1-4]GlcNAc. Furthermore, a fucosyltransferase activity involved in the biosynthesis of this antigen was detected in sycamore cells. This is the first characterization in plants of a Lewis antigen that is usually found on cell-surface glycoconjugates in mammals and involved in recognition and adhesion processes. Le(a)-containing N-linked glycans are widely distributed in plants and highly expressed at the cell surface, which may suggest a putative function in cell/cell communication.

Citations

Mar 1, 2012·Plant Cell Reports·Farooqahmed S KitturJiahua Xie
Dec 6, 2012·Molecular Biotechnology·Hiroyuki KajiuraKazuhito Fujiyama
Dec 2, 1999·Biochimica Et Biophysica Acta·E StaudacherL März
Dec 5, 2002·Current Opinion in Structural Biology·Iain B H Wilson
Jul 19, 2003·European Journal of Biochemistry·Bénédicte Samyn-PetitPhilippe Delannoy
Apr 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jae Sook KangHisashi Koiwa
Apr 12, 2011·The Journal of Biological Chemistry·Heidi Kaulfürst-SobollAntje von Schaewen
Mar 25, 1999·Glycobiology·M Cabanes-MacheteauL Faye
Jun 28, 2008·Journal of Experimental Botany·Hélène GuermonprezSandrine Bonhomme
Dec 14, 1999·Plant Physiology·A NebenführL A Staehelin
Feb 25, 2005·Genome Génome / Conseil National De Recherches Canada·Alexandra CastilhoWanda Viegas
Jun 21, 2012·Canadian Journal of Microbiology·Ofra RachmaninovNechama Gilboa-Garber
Oct 31, 2003·Bioscience, Biotechnology, and Biochemistry·Yoshinobu KimuraSiang Hee Tan
Jan 25, 2005·Bioscience, Biotechnology, and Biochemistry·Yoshinobu KimuraKosuke Kino
Oct 1, 2005·Bioscience, Biotechnology, and Biochemistry·Megumi MaedaYoshinobu Kimura
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·H BakkerD Bosch
Oct 26, 2001·Bioscience, Biotechnology, and Biochemistry·Y KimuraM Kimura
Aug 3, 2010·Expert Review of Vaccines·Dirk Bosch, Arjen Schots

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