N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters

PloS One
Roberto TestaClaudio Franceschi

Abstract

Glycosylation, i.e the enzymatic addition of oligosaccharides (or glycans) to proteins and lipids, known as glycosylation, is one of the most common co-/posttranslational modifications of proteins. Many important biological roles of glycoproteins are modulated by N-linked oligosaccharides. As glucose levels can affect the pathways leading to glycosylation of proteins, we investigated whether metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), pathological conditions characterized by altered glucose levels, are associated with specific modifications in serum N-glycome. We enrolled in the study 562 patients with Type 2 Diabetes Mellitus (T2DM) (mean age 65.6±8.2 years) and 599 healthy control subjects (CTRs) (mean age, 58.5±12.4 years). N-glycome was evaluated in serum glycoproteins. We found significant changes in N-glycan composition in the sera of T2DM patients. In particular, α(1,6)-linked arm monogalactosylated, core-fucosylated diantennary N-glycans (NG1(6)A2F) were significantly reduced in T2DM compared with CTR subjects. Importantly, they were equally reduced in diabetic patients with and without complications (P<0.001) compared with CTRs. Macro vascular-complications were found to be related with decreased level...Continue Reading

References

Mar 1, 1975·Diabetes·R E YodaikenM J McClaren
Apr 1, 1994·Diabetes/metabolism Reviews·B L WajchenbergA T Santomauro
Feb 13, 1997·Biochemical and Biophysical Research Communications·R S HaltiwangerR Scartozzi
Aug 1, 1996·Nature Biotechnology·N JenkinsD C James
Oct 30, 1998·Diabetologia·J C Pickup, M A Crook
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jun 2, 2001·Genome Biology·K J Yarema, C R Bertozzi
Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Koji HigaiKojiro Matsumoto
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Dec 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Maria G Buse
May 10, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·K G M M AlbertiJ Shaw
Sep 9, 2006·Cell·Kazuaki Ohtsubo, Jamey D Marth
Dec 29, 2006·Diabetes Care·UNKNOWN American Diabetes Association
Apr 5, 2007·Nature Protocols·Wouter LaroyNico Callewaert
May 15, 2007·Current Opinion in Lipidology·Veronica Hirsch-Reinshagen, Cheryl L Wellington
Aug 2, 2007·American Journal of Physiology. Endocrinology and Metabolism·Naofumi ItohMasaharu Nishimura
Aug 9, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xue-En LiuCuiying Chen
Oct 18, 2007·Molecular BioSystems·Wagner B Dias, Gerald W Hart
Dec 1, 2007·Rejuvenation Research·Valerie VanhoorenCuiying Chen
Feb 6, 2008·Metabolism: Clinical and Experimental·Pasquale StrazzulloEduardo Farinaro
Apr 24, 2008·Biogerontology·Valerie VanhoorenCuiying Chen
Sep 4, 2009·Glycobiology·Olga GornikGordan Lauc
Nov 13, 2009·Diabetes Care·Avshalom Leibowitz, Ehud Grossman
Nov 16, 2010·Diabetes & Metabolism·T IssadP Pagesy
Dec 1, 2011·Physiological Genomics·Ida G LundeCathrine R Carlson
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Fabio Dall'OlioMariella Chiricolo
Feb 23, 2012·Ageing Research Reviews·Fabio Dall'OlioClaudio Franceschi
May 11, 2012·Glycoconjugate Journal·Helga K EinarsdottirManfred Wuhrer
Oct 16, 2012·The Journal of Clinical Endocrinology and Metabolism·Clare SpringhornM Faadiel Essop
Oct 26, 2012·Current Diabetes Reviews·Thomas Phillip EllisRakesh Chibber
Sep 18, 2014·Diabetology & Metabolic Syndrome·Jason P MyslickiDarrell D Belke

❮ Previous
Next ❯

Citations

Feb 3, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·José Alexandre FerreiraLúcio Lara Santos
Apr 4, 2016·Biochimica Et Biophysica Acta·René HennigErdmann Rapp
Apr 7, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Chris WatsonKen McDonald
Apr 8, 2017·Omics : a Journal of Integrative Biology·Eric AduaWei Wang
Jan 1, 2017·Mechanisms of Ageing and Development·Daniela MontiClaudio Franceschi
Mar 12, 2017·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Aleksandra FucicGordan Lauc
Mar 10, 2018·Expert Review of Proteomics·Arun V Everest-DassNicolle H Packer
Nov 18, 2017·Diabetes Care·Mairead L BerminghamUNKNOWN SDRN Type 1 Bioresource Investigators
Feb 10, 2018·Proteomics. Clinical Applications·Shuang YangJohn Cipollo
Nov 26, 2015·Journal of the American Heart Association·Andrea Vilar-BerguaPilar Delgado
Nov 2, 2018·Expert Review of Proteomics·Wenjing PengYehia Mechref
Nov 21, 2018·Omics : a Journal of Integrative Biology·Qingwei MaWei Wang
May 6, 2019·Proteomics. Clinical Applications·Ana PenezićOlgica Nedić
Sep 12, 2019·FEBS Letters·Viktoria Dotz, Manfred Wuhrer
Jul 4, 2020·BMJ Open Diabetes Research & Care·Sunny S SinghMandy van Hoek
May 16, 2020·Journal of Diabetes Investigation·Yoshitaka HashimotoMichiaki Fukui
Feb 8, 2018·Aging·Alberto MontesantoGiuseppina Rose
Jul 28, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Roberto TestaAntonio Ceriello
Aug 29, 2017·BioFactors·Robertina GiacconiMauro Provinciali
Jan 8, 2016·Glycoconjugate Journal·Monique Van ScherpenzeelDirk J Lefeber
Jul 12, 2017·Omics : a Journal of Integrative Biology·Qing GaoManshu Song
Oct 26, 2018·Circulation Research·Cristina GiulianiClaudio Franceschi
Apr 18, 2018·Frontiers in Medicine·Claudio FranceschiStefano Salvioli
Jul 27, 2018·Nature Reviews. Endocrinology·Claudio FranceschiAurelia Santoro
Oct 23, 2020·Journal of Separation Science·Cristian D Gutierrez ReyesYehia S Mechref
Aug 31, 2020·Molecular Aspects of Medicine·Tamara ŠtambukGordan Lauc
Jan 29, 2021·Journal of Clinical Laboratory Analysis·Chengyun ZouHaiying Wang
May 22, 2020·Journal of Proteome Research·Keita YamadaMitsuhiro Kinoshita
Jun 3, 2021·International Journal of Molecular Sciences·Beatrix PatonNúria Canela
Jan 21, 2017·Analytical Chemistry·Stefan GaunitzMilos V Novotny

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Methods Mentioned

BETA
PCR
glycosylation

Software Mentioned

Robustbase ( CIT
Genescan
multtest
SPSS

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