N-Halamine-Based Antimicrobial Additives for Polymers: Preparation, Characterization and Antimicrobial Activity.

Industrial & Engineering Chemistry Research
Zhaobin Chen, Yuyu Sun

Abstract

A series of 3-alkyl-5,5-dimethylhydantoin derivatives were prepared by reacting 5,5-dimethylhydantoin with alkyl bromides with different alkyl chain length (C-2 to C-22). Upon chlorination, the hydration derivatives were transformed into 1-chloro-3-alkyl-5,5-dimethylhydantoins (CADMH). The structures of the samples were fully characterized with FT-IR, (1)H NMR, UV, and DSC analyses. The antimicrobial functions of CADMH were challenged with 10(8-9) CFU/mL of Escherichia coli (gram-negative bacteria) and Staphylococcus aureus (gram-positive bacteria). All the samples provided a total kill of the gram-negative and gram-positive bacteria in less than 30 min. CADMH were used as antimicrobial additives for polymeric materials. It was found that the presence of as low as 1% of CADMH could provide the samples with potent antimicrobial functions. The structure-antimicrobial efficacy relationships of the CADMH were further discussed.

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