Nov 1, 1975

N-hydroxyamobarbital: the second major metabolite of amobarbital in man

Drug Metabolism and Disposition : the Biological Fate of Chemicals
B K TangW Kalow

Abstract

After oral administration of 14C-labeled amobarbital to healthy subjects, most of the radioactivity was recovered in urine and only 4-5% in feces over a period of 6 days. No unchanged amobarbital was excreted. Two major metabolites were found and isolated. One was 3'-hydroxyamobarbital, which has been previously identified by Maynert. The second could be identified as N-hydroxyamobarbital on the basis of its spectral and chemical properties.

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Mentioned in this Paper

Carmol
Feces
Hydroxylation
Malonates
Barbamyl

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