PMID: 497Dec 1, 1975

N-Isopropyl derivatives of dopamine and 5,6-dihydroxy-2-aminotetralin

Journal of Medicinal Chemistry
J G CannonR J Naylor

Abstract

Secondary and tertiary amino homologs of the title compounds have been prepared, bearing an N-isopropyl group. In peripheral evaluation, certain members of the series exhibited beta-adrenergic agonist effects of lower activity than isoproterenol. N-Methyl-N-isopropyl-5,6-dihydroxytetralin exhibited marked properties consistent with its being an alpha agonist, and it is concluded that introduction of considerable bulk about the nitrogen of a catecholamine does not a priori destroy alpha-agonist effects. The compounds qualitatively paralleled the effects of dopamine in assays based upon direct intrastriatal administration in rats, although they were less potent than dopamine.

Citations

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P H VolkmanT Lee
Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain

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