N-Latex CDT results in liver diseases

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Lech ChrostekMaciej Szmitkowski

Abstract

The aim of this study was to test whether liver diseases of alcoholic and non-alcoholic origin cause false-positive carbohydrate-deficient transferrin (CDT) results when the particle-enhanced immunonephelometry for CDT assays is used and to assess the effect of liver disease severity on N-Latex CDT results. Blood was sampled from 245 newly admitted patients suffering from liver diseases: alcoholic and non-alcoholic cirrhosis (AC), chronic viral (B and C) and non-viral hepatitis, toxic and autoimmune hepatitis (AIH), hepatocellular carcinoma and primary biliary cirrhosis (PBC). CDT was determined by particle-enhanced imunononephelometry using the N-Latex CDT test. There were significant differences in %CDT levels between liver diseases of various etiologies. The %CDT level in AC was higher than that in chronic hepatitis (non-viral and viral C). In turn, the %CDT level in chronic hepatitis C was lower than that in toxic hepatitis. The frequency of false-positive %CDT results in liver diseases of non-alcoholic origin was 13/146, and was highest in AIH (4/14). There were no CDT-positive results in PBC and chronic hepatitis B. The frequency of CDT-positive results in alcoholic liver diseases was 24/59 in cirrhosis and 10/34 in hepat...Continue Reading

References

Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B J PotterS Sherlock
Mar 18, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y MurawakiH Kawasaki
Jan 10, 2002·Alcoholism, Clinical and Experimental Research·A DiMartiniR Anton
Aug 14, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Petra AnttilaOnni Niemelä
Jun 23, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Torsten ArndtAxel M Gressner
Dec 25, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jonas P Bergström, Anders Helander
Apr 30, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Torsten ArndtJos P M Wielders
Jul 28, 2010·Alcoholism, Clinical and Experimental Research·Scott H StewartRaymond F Anton

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Citations

Jul 11, 2016·International Archives of Occupational and Environmental Health·Sonja KiloHans Drexler
Oct 30, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Rachel AakerøyOlav Spigset

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