PMID: 7019775Jul 2, 1981Paper

N-Methyl-D-aspartate acid: a convulsant with weak neurotoxic properties

Neuroscience Letters
R ZaczekJ T Coyle

Abstract

N-Methyl-D-aspartic acid (NMDA) is 100-fold less potent as a neurotoxin than kainic acid when injected into the rat striatum. However, NMDA, when injected into the hippocampus, causes a more severe seizure disorder than kainic acid and doses of NMDA than produce much smaller lesions than those caused by kainate. These results indicate a poor correlation between convulsant and neurotoxic properties of acidic excitatory amino acids.

References

Aug 6, 1979·Life Sciences·J W OlneyJ Labruyere
Aug 1, 1978·European Journal of Pharmacology·R SchwarczJ T Coyle
Nov 1, 1976·British Journal of Pharmacology·T J BiscoeJ C Watkins
Sep 13, 1974·Brain Research·J W OlneyO L Ho
Nov 1, 1962·Journal of Medicinal and Pharmaceutical Chemistry·J C WATKINS

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Citations

Feb 13, 1984·Brain Research·K SandbergJ T Coyle
Jun 4, 1985·Neuroscience Letters·B L Gibson, L Reif-Lehrer
Dec 15, 1990·European Journal of Pharmacology·U MadsenP Krogsgaard-Larsen
Mar 19, 2014·Neurochemistry International·Daniel DahlbergBjørnar Hassel

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