PMID: 11311462Apr 20, 2001Paper

N-methyl-D-aspartate channel and consciousness: from signal coincidence detection to quantum computing

Progress in Neurobiology
A Freitas da RochaF A Bezerra Coutinho

Abstract

Research on Blindsight, Neglect/Extinction and Phantom limb syndromes, as well as electrical measurements of mammalian brain activity, have suggested the dependence of vivid perception on both incoming sensory information at primary sensory cortex and reentrant information from associative cortex. Coherence between incoming and reentrant signals seems to be a necessary condition for (conscious) perception. General reticular activating system and local electrical synchronization are some of the tools used by the brain to establish coarse coherence at the sensory cortex, upon which biochemical processes are coordinated. Besides electrical synchrony and chemical modulation at the synapse, a central mechanism supporting such a coherence is the N-methyl-D-aspartate channel, working as a 'coincidence detector' for an incoming signal causing the depolarization necessary to remove Mg(2+), and reentrant information releasing the glutamate that finally prompts Ca(2+) entry. We propose that a signal transduction pathway activated by Ca(2+) entry into cortical neurons is in charge of triggering a quantum computational process that accelerates inter-neuronal communication, thus solving systemic conflict and supporting the unity of conscious...Continue Reading

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Citations

Mar 29, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hongliang Liu, Shanglong Yao
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Oct 19, 2004·Medical Hypotheses·A F RochaF A B Coutinho
Sep 24, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Enver MelikTuncay Ozgunen
Jul 12, 2014·Journal of Integrative Neuroscience·Alfredo Pereira
Nov 21, 2017·Journal of Integrative Neuroscience·Massimo PregnolatoAlfredo Pereira

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