N-methyl-D-aspartate enhancement of phasic responses in primate neocortex

Experimental Brain Research
C E SchroederJ C Arezzo

Abstract

In area 17 of the awake macaque, disinhibition by blockade of GABA(A) receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-D-aspartate (NMDA)-mediated. Laminar activity profiles consisting of flash-evoked field potential, current source density (CSD) and multiunit activity (MUA) measures were obtained during striate cortex penetrations using multicontact electrodes that incorporated single or double microinjection cannulae. Profiles were recorded before and at successive time points after bicuculline induction of disinhibition. Both the noncompetitive NMDA antagonist MK-801 and the competitive antagonist APV reversed bicuculline effects, producing a normal laminar activity profile. NMDA-mediated enhancement of excitatory responses in the supragranular laminae of neocortex is believed to play a role in normal signal processing, as well as in epileptic manifestations.

Citations

Oct 26, 2012·Journal of Computational Neuroscience·Aaditya V Rangan, Lai-Sang Young
Jun 14, 2002·Brain Research. Cognitive Brain Research·Charles E Schroeder, John J Foxe
Dec 8, 2007·Nature Reviews. Drug Discovery·Daniel C JavittMihály Hajós
Aug 3, 2000·The Journal of the Acoustical Society of America·Y I FishmanM Steinschneider
Aug 3, 2000·The Journal of the Acoustical Society of America·Y I FishmanM Steinschneider
Jul 22, 1998·The Journal of the Acoustical Society of America·A Sharma, M F Dorman
Dec 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aaditya V RanganDavid W McLaughlin
Apr 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·David CaiDavid W McLaughlin
Jul 1, 1997·Electroencephalography and Clinical Neurophysiology·T McGeeT Nicol
Nov 7, 2007·Neuroimaging Clinics of North America·Steven M Stufflebeam, Bruce R Rosen
Feb 28, 2015·Annals of the New York Academy of Sciences·Daniel C Javitt
Jun 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Aaditya V RanganDavid Cai
Sep 15, 2012·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kazuhito Ikeda
Aug 28, 2020·Science Advances·Marcin LeszczyńskiCharles E Schroeder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.