N-methyl-D-aspartate (NMDA) receptors in the spinal cord and motor cortex in motor neuron disease: a quantitative autoradiographic study using [3H]MK-801

Brain Research
P J ShawJ M Candy

Abstract

The distribution and density of NMDA receptors in spinal cord and motor cortex was compared in motor neuron disease (MND; 10 cases) and controls (8 cases) using [3H]MK-801 autoradiography. In the spinal ventral horn of MND cases, [3H]MK-801 binding was reduced and there were fewer focal hot spots of binding. These changes are likely to reflect loss of motor neurons (MN) bearing NMDA receptors. [3H]MK-801 binding was increased in intermediate spinal grey matter and deeper layers of the motor cortex in MND cases compared to controls. This may represent either an adaptive response to MN loss or a pathophysiological phenomenon contributing to MN degeneration.

References

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Citations

May 1, 1997·Journal of Neurology·P J Shaw, P G Ince
Jun 3, 1996·European Journal of Pharmacology·A BrambillaF Borsini
Jul 1, 1994·Journal of the Neurological Sciences·P J Shaw
Mar 1, 1996·Trends in Pharmacological Sciences·C KriegerC A Shaw
Jun 1, 1997·Brain Research. Brain Research Reviews·R E Coggeshall, S M Carlton
Feb 5, 1998·Brain Research. Molecular Brain Research·I D MiltonP J Shaw
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Jul 22, 2009·Molecular Neurodegeneration·Luis B Tovar-Y-RomoRicardo Tapia

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