N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica.

Annals of Neurology
Russell C DaleAngela Vincent

Abstract

Encephalitis lethargica (EL) describes an encephalitis with psychiatric, sleep, and extrapyramidal movement disorders. Dyskinetic and parkinsonian forms have been described. EL shares clinical features with the anti-N-methyl-D-aspartate receptor (NMDAR-Ab) encephalitis. We studied 20 sera from pediatric patients with contemporary EL. Ten sera (from 2 males and 8 females, aged 1.3-13 years) and 6/6 cerebrospinal fluid samples were positive for NMDAR-Ab. NMDAR-Ab-positive patients had dyskinesias, agitation, seizures, and insomnia, whereas parkinsonism and somnolence dominated in the NMDAR-Ab-negative children. We were unable to identify any tumors. The dyskinetic form of EL is an NMDAR-Ab encephalitis and can affect very young children.

References

Feb 1, 1987·Brain : a Journal of Neurology·R S Howard, A J Lees
May 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·S B BluntG D Perkin
Jun 1, 1997·Acta Neurologica Scandinavica·K NokuraK Sakai
Aug 16, 1997·Lancet·H OkamuraY Uchitomi
May 9, 2002·Developmental Medicine and Child Neurology·L M HartleyC de Sousa
Oct 23, 2003·Brain : a Journal of Neurology·Russell C DaleGavin Giovannoni
Dec 17, 2005·Journal of Neuroimmunology·Russell C DaleGavin Giovannoni
May 2, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·S RaghavP A Kempster
Mar 24, 2007·Internal Medicine·Yoichi OnoKoji Abe
Oct 5, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Russell C DaleDeepak Gill
Apr 30, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Timothy J KleinigPeter C Blumbergs
Jul 16, 2008·Archives of Neurology·Patrick WatersAngela Vincent
Mar 25, 2009·Archives of Disease in Childhood·M SchimmelJ Penzien

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Citations

Mar 23, 2011·Der Nervenarzt·M A Friese, T Magnus
Feb 8, 2011·Current Treatment Options in Neurology·Myrna R Rosenfeld, Josep Dalmau
Oct 16, 2012·Brain : a Journal of Neurology·Russell C DaleFabienne Brilot
Nov 22, 2012·Brain : a Journal of Neurology·Ming Lim, Angela Vincent
Jan 28, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mary S GableCarol A Glaser
Sep 28, 2010·Current Opinion in Pediatrics·Russell C Dale, Fabienne Brilot
Oct 5, 2010·Current Opinion in Pediatrics·Silvia N Tenembaum
Nov 4, 2010·Current Opinion in Pediatrics·Nicole Florance-Ryan, Josep Dalmau
May 18, 2011·Current Opinion in Neurology·Jessica Panzer, Josep Dalmau
Jun 1, 2013·Acta Neuropsychiatrica·Peter MaatPeter A Sillevis Smitt
Mar 27, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Luigi ZulianiAngela Vincent
Sep 1, 2012·Journal of Child Neurology·Thaís ArmangueJosep Dalmau
Jul 19, 2011·Therapeutic Advances in Neurological Disorders·Wolfgang GrisoldStefan Oberndorfer
May 19, 2010·The Oncologist·Myrna R Rosenfeld, Josep Dalmau
Oct 6, 2012·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Imer Önder SlettedalPetter Strømme
Nov 20, 2013·Neuroscience and Biobehavioral Reviews·Keith A FeigensonSteven M Silverstein
Sep 26, 2013·Clinical & Developmental Immunology·Karrnan PathmanandavelFabienne Brilot
Dec 4, 2012·Autoimmunity Reviews·Angela Vincent
Mar 19, 2014·Neuro-oncology·Josep Dalmau, Myrna R Rosenfeld
Feb 22, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Lily C Wong-KisielElaine C Wirrell
Apr 22, 2014·Brain & Development·Ibtihel RebaiNeziha Gouider-Khouja
Sep 2, 2010·Rinshō shinkeigaku = Clinical neurology·Rie MotoyamaMasami Tanaka
Nov 12, 2013·Brain & Development·Kazushi MiyaHisashi Mori
Aug 31, 2013·Biological Psychiatry·Julia DeakinMichael S Zandi
Apr 24, 2013·Neuroimaging Clinics of North America·Kevin Charles JonesMahendranath Moharir
Oct 23, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·J González-ValcárcelJ Dalmau
Jul 23, 2011·Lancet Neurology·Angela VincentPatrick Waters
Sep 15, 2010·Pediatric Neurology·Sophelia H S ChanAngela Vincent
Aug 10, 2010·Pediatric Neurology·Hiroshi SakumaMasayuki Sasaki
Aug 10, 2010·Pediatric Neurology·Sekhar C PillaiRussell C Dale
Jul 8, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Aaron TanChristopher Bladin
Nov 16, 2012·Developmental Medicine and Child Neurology·Russell C DaleFabienne Brilot
Oct 26, 2012·Developmental Medicine and Child Neurology·Adriane J SinclairRussell C Dale
May 18, 2011·Developmental Medicine and Child Neurology·Russell C DaleFabienne Brilot
Jun 17, 2014·Annals of Neurology·Sarosh R IraniAngela Vincent
Aug 27, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Shekeeb S MohammadRussell C Dale
Oct 17, 2013·Developmental Medicine and Child Neurology·Yael HacohenMing Lim
May 4, 2010·Annals of Neurology·Michael P MalterChristian G Bien
Oct 16, 2014·Annals of the New York Academy of Sciences·Frank LeypoldtJosep Dalmau
Jun 18, 2015·Annals of the New York Academy of Sciences·Nese SinmazFabienne Brilot

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