N-methyl-D-aspartate receptors containing the NR2D subunit in the retina are selectively expressed in rod bipolar cells

Neuroscience
A WenzelJ M Fritschy

Abstract

N-methyl-D-aspartate receptor subunit messenger RNAs are widely expressed in the retina and several types of second and third order neurons are responsive to N-methyl-D-aspartate. Functional N-methyl-D-aspartate receptors are assembled from the NR1 subunit with at least one of the four NR2 subunit variants (NR2A-2D). We have analysed immunohistochemically the cellular distribution of N-methyl-D-aspartate receptors containing the NR2D subunit in the rat and rabbit retina. Using a subunit-specific NR2D antiserum, exclusively bipolar cells with somata localized close to the outer plexiform layer were labelled in both species. The axons were immunoreactive and arborized in the innermost inner plexiform layer. The morphology and localization of these cells, which were much more numerous in rat than in rabbit, suggested that they are rod bipolar cells. This was confirmed in both species by co-localization of the NR2D subunit immunoreactivity with protein kinase C-alpha, a selective marker for rod bipolar cells. At the subcellular level, a distinct polarization in the distribution of NR2D immunoreactivity was demonstrated by confocal laser scanning microscopy: staining was moderate in dendrites arborizing within the outer plexiform la...Continue Reading

References

Apr 13, 1992·Neuroscience Letters·F MüllerP Seeburg
Jun 1, 1992·Visual Neuroscience·R SiliprandiG Vantini
Nov 22, 1990·Proceedings. Biological Sciences·R A Shiells, G Falk
Aug 8, 1991·The Journal of Comparative Neurology·H M Young, D I Vaney
May 1, 1991·Journal of Neurochemistry·A M Young, H F Bradford
Nov 15, 1990·The Journal of Comparative Neurology·U GreferathH Wässle
Apr 1, 1990·Journal of Neurophysiology·A Karschin, H Wässle
May 15, 1990·The Journal of Comparative Neurology·E StrettoiE Raviola
Dec 15, 1987·The Journal of Comparative Neurology·M A FreedP Sterling
Aug 1, 1995·Journal of Neurophysiology·M A Gillette, R F Dacheux
Aug 16, 1994·European Journal of Pharmacology·D J Laurie, P H Seeburg
Feb 1, 1995·Neuropharmacology·B Bettler, C Mulle
Oct 22, 1994·The Journal of Comparative Neurology·E HartveitH Wässle
Jul 1, 1994·The European Journal of Neuroscience·J H BrandstätterH Wässle
May 1, 1994·The Journal of Comparative Neurology·D G StandaertJ B Penney
Jul 1, 1994·Physiological Reviews·C J McBain, M L Mayer
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·H LiuA I Basbaum
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·S J SiegelJ H Morrison
Jun 22, 1993·The Journal of Comparative Neurology·M H ChunH Wässle
Oct 23, 1995·The Journal of Comparative Neurology·T Euler, H Wässle
Oct 1, 1995·Neuropharmacology·H Mori, M Mishina

❮ Previous
Next ❯

Citations

Dec 18, 2001·The Journal of Comparative Neurology·A Silveira dos Santos Bredariol, D E Hamassaki-Britto
Jul 18, 2001·Brain Research. Molecular Brain Research·J Xue, N G Cooper
Oct 26, 1999·Progress in Retinal and Eye Research·W B Thoreson, P Witkovsky
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·M CasadoP Ascher
Apr 3, 2001·The Journal of Comparative Neurology·R G PourchoD J Goebel
Mar 6, 2012·Acta histochemica·Lily Alexandrova Vitanova
Jun 2, 2009·Journal of Chemical Neuroanatomy·Jan KloosterMaarten Kamermans
Dec 21, 2006·The Journal of Comparative Neurology·Monica L AcostaMichael Kalloniatis
Jul 17, 1998·Vision Research·J H BrandstätterH Wässle
Jul 23, 1998·The Journal of Comparative Neurology·P KoulenH Wässle
Jan 6, 2012·Neurología : publicación oficial de la Sociedad Española de Neurología·M E Flores-SotoC Beas-Zarate
Dec 22, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Catherine A OpereNajam A Sharif
Jun 2, 2006·Journal of Neurophysiology·Timm SchubertAndreas Feigenspan
Aug 24, 2007·Journal of Neurophysiology·Robert P BoninBeverley A Orser
Nov 18, 2000·Journal of Neurochemistry·S SeeberM Herkert
Aug 31, 2021·European Journal of Pharmacology·Vahid Shafiei-IrannejadHamid Soraya

❮ Previous
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