PMID: 9630004Jun 18, 1998Paper

N-methyl-D-aspartate receptors in the nucleus accumbens are involved in detection of spatial novelty in mice

Psychopharmacology
A UsielloA Mele

Abstract

The aim of this study was to investigate the role played by intra-accumbens N-methyl-D-aspartate (NMDA) receptors in spatial information encoding. For this purpose, the effect of local administration of both competitive (AP-5) and non-competitive (MK-801) NMDA antagonists was assessed in a task designed to estimate the ability of rodents to encode spatial relationships between discrete stimuli. The task consists of placing mice in an open field containing five objects and, after three sessions of habituation, examining their reactivity to object displacement (spatial novelty) and object substitution (object novelty). The results show that both doses of MK-801 (0.15 and 0.3 microg/side) induced a selective impairment in the capability of mice to detect spatial novelty. A similar effect was obtained by injecting the low dose of the competitive antagonist AP-5 (0.1 microg/side), whereas the high dose (0.15 microg/side) abolished detection of both spatial and object novelty. Taken together, these results show that intra-accumbens injections of low doses of competitive and non-competitive NMDA antagonists can produce selective deficits in processing spatial information resembling those observed after hippocampal damage. Moreover, th...Continue Reading

Citations

Jun 5, 2002·Physiology & Behavior·Gabriel MartínezPascual A Gargiulo
Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·M R TinsleyW Timberlake
Oct 19, 2002·Behavioural Brain Research·Gemma CalamandreiLaura Ricceri
Mar 19, 2003·Behavioural Brain Research·Sean ComminsDerek Walsh
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Jan 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roberto CoccurelloAndrea Mele
Sep 3, 2004·Behavioural Pharmacology·A MeleA Oliverio
Jun 3, 2014·Pharmacology, Biochemistry, and Behavior·Larissa KochenborgerMoacir Serralvo Faria
Mar 24, 2009·Physiology & Behavior·Michel Pratte, Marc Jamon
May 20, 2003·The European Journal of Neuroscience·Ranier GutiérrezFederico Bermúdez-Rattoni
Oct 4, 2011·Progress in Neurobiology·Marsha R Penner, Sheri J Y Mizumori
Mar 1, 2006·Current Protocols in Toxicology·Igor Branchi, Laura Ricceri
Nov 2, 2016·Behavioural Pharmacology·Cheng J YuFa D Tai

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