N-myc downstream-regulated gene 2 protects blood-brain barrier integrity following cerebral ischemia

Glia
Mika Takarada-IemataOsamu Hori

Abstract

Disruption of the blood-brain barrier (BBB) following cerebral ischemia is closely related to the infiltration of peripheral cells into the brain, progression of lesion formation, and clinical exacerbation. However, the mechanism that regulates BBB integrity, especially after permanent ischemia, remains unclear. Here, we present evidence that astrocytic N-myc downstream-regulated gene 2 (NDRG2), a differentiation- and stress-associated molecule, may function as a modulator of BBB permeability following ischemic stroke, using a mouse model of permanent cerebral ischemia. Immunohistological analysis showed that the expression of NDRG2 increases dominantly in astrocytes following permanent middle cerebral artery occlusion (MCAO). Genetic deletion of Ndrg2 exhibited enhanced levels of infarct volume and accumulation of immune cells into the ipsilateral brain hemisphere following ischemia. Extravasation of serum proteins including fibrinogen and immunoglobulin, after MCAO, was enhanced at the ischemic core and perivascular region of the peri-infarct area in the ipsilateral cortex of Ndrg2-deficient mice. Furthermore, the expression of matrix metalloproteinases (MMPs) after MCAO markedly increased in Ndrg2-/- mice. In culture, expres...Continue Reading

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Citations

Apr 21, 2019·Journal of Cellular Physiology·Zengli ZhangYulong Ma
May 30, 2020·Experimental Physiology·Bilal A MirVictoria C Foletta
Dec 14, 2019·Cellular and Molecular Life Sciences : CMLS·Xin LiLize Xiong
Jan 18, 2020·International Journal of Molecular Sciences·Motaz M FadulJulie E Simpson
Jan 1, 2021·CNS Neuroscience & Therapeutics·Xiaowen HuangJunlei Chang
Dec 29, 2020·Neuroscience Letters·Mika Takarada-IemataOsamu Hori
Jul 21, 2020·Brain, Behavior, and Immunity·Hao ChengJun Tang
Jul 2, 2021·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Mika Takarada-Iemata, Osamu Hori

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