N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-α and nuclear factor kappa B, aggravates cardiac ischemia/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway

Basic Research in Cardiology
Yuan XingYuan-qiang Zhang

Abstract

N-myc downstream-regulated gene 4 (NDRG4) is expressed weakly in heart and has been reported to modulate cardiac development and QT interval duration, but the role of NDRG4 in myocardial ischemia/reperfusion (I/R) injury remains unknown. In the present study, we analyzed the expression as well as potential function of cardiac NDRG4 and investigated how NDRG4 expression is regulated by inflammation. We found that NDRG4 was weakly expressed in cardiomyocytes and that its expression increased significantly both in I/R injured heart and in hypoxia-reoxygenation (H/R) injured neonatal rat ventricular myocytes (NRVMs). The increased NDRG4 expression aggravated myocardial I/R injury by inhibiting the activation of the reperfusion injury salvage kinase (RISK) pathway. Forced over-expression of NDRG4 inhibited RISK activation and exacerbated injury not only in I/R injured heart, but also in H/R treated NRVMs, whereas short hairpin RNA (shRNA)-mediated knock-down of NDRG4 enhanced RISK activation and attenuated injury. Upon injury, myocardial NDRG4 expression was induced by tumor necrosis factor-α (TNF-α) through nuclear factor kappa B (NF-κB), and we found that pre-treatment with inhibitors of either TNF-α or NF-κB blocked NDRG4 express...Continue Reading

References

Jun 19, 2001·Biochimica Et Biophysica Acta·W ZhaoY Mao
Mar 30, 2002·Journal of the American College of Cardiology·Naoya MaekawaMitsuru Seishima
Dec 31, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Cuihua ZhangWilliam M Chilian
Aug 22, 2006·Carcinogenesis·Zaklina Kovacevic, Des R Richardson
Apr 7, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Xue GaoCuihua Zhang
Jun 2, 2007·Heart Failure Reviews·Derek J Hausenloy, Derek M Yellon
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Libo YaoXuewu Liu
Nov 1, 2008·International Journal of Cancer. Journal International Du Cancer·Weiqun WangRunsheng Li
Nov 29, 2008·Circulation Research·Andreas SkyschallyGerd Heusch
Mar 24, 2009·Nature Genetics·Christopher Newton-ChehBruno H Ch Stricker
Jun 19, 2009·Journal of the National Cancer Institute·Veerle MelotteManon van Engeland
Jul 14, 2009·The Journal of Biological Chemistry·Stephen H SchillingMichael B Datto
Jun 24, 2010·Heart Failure Reviews·Petra KleinbongardGerd Heusch
Jun 4, 2011·The Journal of Biological Chemistry·Hitomi YamamotoToshiyuki Miyata
Jan 17, 2012·Molecular Medicine Reports·Zhongqiu WangZhenjuan Liu
Apr 12, 2012·Omics : a Journal of Integrative Biology·Wenchao DingBiaoyang Lin
Aug 8, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Rama P KotipatruniJerry J Jaboin
Aug 11, 2012·International Review of Cell and Molecular Biology·Theodore KalogerisRonald J Korthuis
Oct 12, 2012·PloS One·Min ZengBo Zhao
Aug 6, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Xiu Q ZhangCraig H Selzman

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Citations

May 20, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N VaesV Melotte
Feb 18, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yanwen Li, Shikun Liu

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