N-Octyl-O-sulfate chitosan stabilises single wall carbon nanotubes in aqueous media and bestows biocompatibility

Nanoscale
Marta RoldoDimitrios G Fatouros

Abstract

A non-covalent approach to debundle single wall carbon nanotubes using a biocompatible chitosan-derivative, namely N-octyl-O-sulfate chitosan (NOSC), was investigated. The resulting stable dispersions were characterised by Raman spectroscopy, UV-Vis spectroscopy, atomic force microscopy (AFM), transmission electron microscopy (TEM) and zeta-potential measurements. Both AFM and TEM studies revealed the presence of individual carbon nanotubes wrapped with the polymer (diameters up to 7 nm). Raman spectra showed radial breathing mode frequency shifts, after the addition of NOSC, due to the wrapping of the biomolecules onto the graphitic sidewalls. Molecular modelling studies were employed to investigate the mode of binding of the NOSC chains to the surface of the nanotubes. In agreement with the experiments, modelling studies predicted that the wrapped tube has a maximum thickness of approximately 7 nm. Studies on the anticoagulant properties of these complexes revealed that NOSC coated SWCNTs exhibit similar activity to the polymer alone, this property would eliminate the risk for SWCNTs to induce coagulation as a host reaction process when used in vivo.

References

Jul 12, 2002·Carbohydrate Research·Preeyanat VongchanPrachya Kongtawelert
Dec 3, 2002·Science·Sergei M BachiloR Bruce Weisman
May 14, 2003·Journal of Colloid and Interface Science·Linqin JiangJing Sun
Dec 9, 2004·Chemical Reviews·M N V Ravi KumarA J Domb
Mar 10, 2005·Journal of the American Chemical Society·Vladimir A SinaniNicholas A Kotov
Mar 31, 2005·Advances in Food and Nutrition Research·Fereidoon Shahidi, Reem Abuzaytoun
Aug 25, 2005·IEEE Transactions on Nanobioscience·Niraj Sinha, John T W Yeow
Oct 20, 2005·Current Opinion in Chemical Biology·Alberto BiancoMaurizio Prato
Nov 15, 2005·Biomacromolecules·Shao-Feng WangYue-Jin Tong
Feb 14, 2006·The Journal of Physical Chemistry. B·Yonnie WuPu Chun Ke
Mar 9, 2006·Chemical Reviews·Dimitrios TasisMaurizio Prato
Mar 22, 2006·Chemical Communications : Chem Comm·Hui YangDaniel L Akins
Apr 6, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Saravanababu MurugesanRobert J Linhardt
Aug 9, 2006·International Journal of Biological Macromolecules·R JayakumarH Tamura
Oct 10, 2006·Journal of Nanoscience and Nanotechnology·Stefania PolizuL'Hocine Yahia
Mar 14, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Can ZhangQineng Ping
Apr 30, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Reto HaggenmuellerJeffrey W Gilman
Jul 26, 2008·Nature Nanotechnology·Sang-Yong JuFotios Papadimitrakopoulos
Dec 9, 2008·Journal of Chemical Theory and Computation·Eduardo F FrancaT P Straatsma

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Citations

Apr 24, 2012·Journal of the American Chemical Society·Alberto NaldoniVladimiro Dal Santo
Aug 2, 2012·Journal of the American Chemical Society·Wei-Li LiLai-Sheng Wang
Sep 28, 2016·Journal of Molecular Graphics & Modelling·Chompoonut RungnimRungtiva P Poo-Arporn
May 24, 2018·Nanoscale·Sushant GhimireVasudevanpillai Biju
Jun 22, 2016·Journal of Materials Science. Materials in Medicine·Giulia CancianMarta Roldo

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